MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis

MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis

ABSTRACT While dispensable for viral replication, coronavirus (CoV) accessory open reading frame (ORF) proteins often play critical roles during infection and pathogenesis. Utilizing a previously generated mutant, we demonstrate that the absence of all four Middle East respiratory syndrome CoV (MERS...

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Autores principales: Vineet D. Menachery, Hugh D. Mitchell, Adam S. Cockrell, Lisa E. Gralinski, Boyd L. Yount, Rachel L. Graham, Eileen T. McAnarney, Madeline G. Douglas, Trevor Scobey, Anne Beall, Kenneth Dinnon, Jacob F. Kocher, Andrew E. Hale, Kelly G. Stratton, Katrina M. Waters, Ralph S. Baric
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
coronavirus
MERS-CoV
SARS-CoV
live vector vaccines
reverse genetics
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/438eeeef29a24edba2f4d738b85fb4c0
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https://doaj.org/article/438eeeef29a24edba2f4d738b85fb4c0

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