MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis

MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis

ABSTRACT While dispensable for viral replication, coronavirus (CoV) accessory open reading frame (ORF) proteins often play critical roles during infection and pathogenesis. Utilizing a previously generated mutant, we demonstrate that the absence of all four Middle East respiratory syndrome CoV (MERS...

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Auteurs principaux: Vineet D. Menachery, Hugh D. Mitchell, Adam S. Cockrell, Lisa E. Gralinski, Boyd L. Yount, Rachel L. Graham, Eileen T. McAnarney, Madeline G. Douglas, Trevor Scobey, Anne Beall, Kenneth Dinnon, Jacob F. Kocher, Andrew E. Hale, Kelly G. Stratton, Katrina M. Waters, Ralph S. Baric
Format: article
Langue:EN
Publié: American Society for Microbiology 2017
Sujets:
coronavirus
MERS-CoV
SARS-CoV
live vector vaccines
reverse genetics
Microbiology
QR1-502
Accès en ligne:https://doaj.org/article/438eeeef29a24edba2f4d738b85fb4c0
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https://doaj.org/article/438eeeef29a24edba2f4d738b85fb4c0

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