Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells

The reasons why influenza infection promotes a broader antibody response compared with vaccines are not fully understood. Here the authors show that unmasking of haemagglutinin epitopes and IL-4 signals in the germinal centre contribute to broader antibody responses after infection.

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Autores principales:	Kosuke Miyauchi, Yu Adachi, Keisuke Tonouchi, Taiki Yajima, Yasuyo Harada, Hidehiro Fukuyama, Senka Deno, Yoichiro Iwakura, Akihiko Yoshimura, Hideki Hasegawa, Katsuyuki Yugi, Shin-ichiro Fujii, Osamu Ohara, Yoshimasa Takahashi, Masato Kubo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/439271e19f7845d6b2e4d127336088a7
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spelling	oai:doaj.org-article:439271e19f7845d6b2e4d127336088a72021-12-02T16:04:29ZInfluenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells10.1038/s41467-021-24090-z2041-1723https://doaj.org/article/439271e19f7845d6b2e4d127336088a72021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24090-zhttps://doaj.org/toc/2041-1723The reasons why influenza infection promotes a broader antibody response compared with vaccines are not fully understood. Here the authors show that unmasking of haemagglutinin epitopes and IL-4 signals in the germinal centre contribute to broader antibody responses after infection.Kosuke MiyauchiYu AdachiKeisuke TonouchiTaiki YajimaYasuyo HaradaHidehiro FukuyamaSenka DenoYoichiro IwakuraAkihiko YoshimuraHideki HasegawaKatsuyuki YugiShin-ichiro FujiiOsamu OharaYoshimasa TakahashiMasato KuboNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kosuke Miyauchi Yu Adachi Keisuke Tonouchi Taiki Yajima Yasuyo Harada Hidehiro Fukuyama Senka Deno Yoichiro Iwakura Akihiko Yoshimura Hideki Hasegawa Katsuyuki Yugi Shin-ichiro Fujii Osamu Ohara Yoshimasa Takahashi Masato Kubo Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells
description	The reasons why influenza infection promotes a broader antibody response compared with vaccines are not fully understood. Here the authors show that unmasking of haemagglutinin epitopes and IL-4 signals in the germinal centre contribute to broader antibody responses after infection.
format	article
author	Kosuke Miyauchi Yu Adachi Keisuke Tonouchi Taiki Yajima Yasuyo Harada Hidehiro Fukuyama Senka Deno Yoichiro Iwakura Akihiko Yoshimura Hideki Hasegawa Katsuyuki Yugi Shin-ichiro Fujii Osamu Ohara Yoshimasa Takahashi Masato Kubo
author_facet	Kosuke Miyauchi Yu Adachi Keisuke Tonouchi Taiki Yajima Yasuyo Harada Hidehiro Fukuyama Senka Deno Yoichiro Iwakura Akihiko Yoshimura Hideki Hasegawa Katsuyuki Yugi Shin-ichiro Fujii Osamu Ohara Yoshimasa Takahashi Masato Kubo
author_sort	Kosuke Miyauchi
title	Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells
title_short	Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells
title_full	Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells
title_fullStr	Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells
title_full_unstemmed	Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells
title_sort	influenza virus infection expands the breadth of antibody responses through il-4 signalling in b cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/439271e19f7845d6b2e4d127336088a7
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Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells

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