Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells

The reasons why influenza infection promotes a broader antibody response compared with vaccines are not fully understood. Here the authors show that unmasking of haemagglutinin epitopes and IL-4 signals in the germinal centre contribute to broader antibody responses after infection.

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Kosuke Miyauchi, Yu Adachi, Keisuke Tonouchi, Taiki Yajima, Yasuyo Harada, Hidehiro Fukuyama, Senka Deno, Yoichiro Iwakura, Akihiko Yoshimura, Hideki Hasegawa, Katsuyuki Yugi, Shin-ichiro Fujii, Osamu Ohara, Yoshimasa Takahashi, Masato Kubo
Format: article
Langue:EN
Publié: Nature Portfolio 2021
Sujets:
Q
Accès en ligne:https://doaj.org/article/439271e19f7845d6b2e4d127336088a7
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!