Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells

During atherosclerosis, endothelial cells release purines in response to oxidized phospholipids. Here, Hitzel et al. show that oxidized phospholipids activate an MTHFD2-regulated gene network in endothelial cells which reprograms amino acid metabolism towards production of purines and thus compensat...

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Autores principales:	Juliane Hitzel, Eunjee Lee, Yi Zhang, Sofia Iris Bibli, Xiaogang Li, Sven Zukunft, Beatrice Pflüger, Jiong Hu, Christoph Schürmann, Andrea Estefania Vasconez, James A. Oo, Adelheid Kratzer, Sandeep Kumar, Flávia Rezende, Ivana Josipovic, Dominique Thomas, Hector Giral, Yannick Schreiber, Gerd Geisslinger, Christian Fork, Xia Yang, Fragiska Sigala, Casey E. Romanoski, Jens Kroll, Hanjoong Jo, Ulf Landmesser, Aldons J. Lusis, Dmitry Namgaladze, Ingrid Fleming, Matthias S. Leisegang, Jun Zhu, Ralf P. Brandes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4401176dc9754aceb3a9a13dbd4a3e34
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id	oai:doaj.org-article:4401176dc9754aceb3a9a13dbd4a3e34
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spelling	oai:doaj.org-article:4401176dc9754aceb3a9a13dbd4a3e342021-12-02T17:32:16ZOxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells10.1038/s41467-018-04602-02041-1723https://doaj.org/article/4401176dc9754aceb3a9a13dbd4a3e342018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04602-0https://doaj.org/toc/2041-1723During atherosclerosis, endothelial cells release purines in response to oxidized phospholipids. Here, Hitzel et al. show that oxidized phospholipids activate an MTHFD2-regulated gene network in endothelial cells which reprograms amino acid metabolism towards production of purines and thus compensates for their loss.Juliane HitzelEunjee LeeYi ZhangSofia Iris BibliXiaogang LiSven ZukunftBeatrice PflügerJiong HuChristoph SchürmannAndrea Estefania VasconezJames A. OoAdelheid KratzerSandeep KumarFlávia RezendeIvana JosipovicDominique ThomasHector GiralYannick SchreiberGerd GeisslingerChristian ForkXia YangFragiska SigalaCasey E. RomanoskiJens KrollHanjoong JoUlf LandmesserAldons J. LusisDmitry NamgaladzeIngrid FlemingMatthias S. LeisegangJun ZhuRalf P. BrandesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Juliane Hitzel Eunjee Lee Yi Zhang Sofia Iris Bibli Xiaogang Li Sven Zukunft Beatrice Pflüger Jiong Hu Christoph Schürmann Andrea Estefania Vasconez James A. Oo Adelheid Kratzer Sandeep Kumar Flávia Rezende Ivana Josipovic Dominique Thomas Hector Giral Yannick Schreiber Gerd Geisslinger Christian Fork Xia Yang Fragiska Sigala Casey E. Romanoski Jens Kroll Hanjoong Jo Ulf Landmesser Aldons J. Lusis Dmitry Namgaladze Ingrid Fleming Matthias S. Leisegang Jun Zhu Ralf P. Brandes Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells
description	During atherosclerosis, endothelial cells release purines in response to oxidized phospholipids. Here, Hitzel et al. show that oxidized phospholipids activate an MTHFD2-regulated gene network in endothelial cells which reprograms amino acid metabolism towards production of purines and thus compensates for their loss.
format	article
author	Juliane Hitzel Eunjee Lee Yi Zhang Sofia Iris Bibli Xiaogang Li Sven Zukunft Beatrice Pflüger Jiong Hu Christoph Schürmann Andrea Estefania Vasconez James A. Oo Adelheid Kratzer Sandeep Kumar Flávia Rezende Ivana Josipovic Dominique Thomas Hector Giral Yannick Schreiber Gerd Geisslinger Christian Fork Xia Yang Fragiska Sigala Casey E. Romanoski Jens Kroll Hanjoong Jo Ulf Landmesser Aldons J. Lusis Dmitry Namgaladze Ingrid Fleming Matthias S. Leisegang Jun Zhu Ralf P. Brandes
author_facet	Juliane Hitzel Eunjee Lee Yi Zhang Sofia Iris Bibli Xiaogang Li Sven Zukunft Beatrice Pflüger Jiong Hu Christoph Schürmann Andrea Estefania Vasconez James A. Oo Adelheid Kratzer Sandeep Kumar Flávia Rezende Ivana Josipovic Dominique Thomas Hector Giral Yannick Schreiber Gerd Geisslinger Christian Fork Xia Yang Fragiska Sigala Casey E. Romanoski Jens Kroll Hanjoong Jo Ulf Landmesser Aldons J. Lusis Dmitry Namgaladze Ingrid Fleming Matthias S. Leisegang Jun Zhu Ralf P. Brandes
author_sort	Juliane Hitzel
title	Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells
title_short	Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells
title_full	Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells
title_fullStr	Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells
title_full_unstemmed	Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells
title_sort	oxidized phospholipids regulate amino acid metabolism through mthfd2 to facilitate nucleotide release in endothelial cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4401176dc9754aceb3a9a13dbd4a3e34
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Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells

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