Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism

Dumitru et al. probe the ligand-binding mechanism and activation of the human G protein-coupled C5a receptor (C5aR) and discover a cooperativity between the two orthosteric binding sites. Their findings, probing the dynamic aspects of receptor–ligand interaction, are valuable to develop a better und...

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Autores principales: Andra C. Dumitru, R. N. V. Krishna Deepak, Heng Liu, Melanie Koehler, Cheng Zhang, Hao Fan, David Alsteens
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/443aebd51a024799afe9304b404255fe
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