The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis

The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis

Receptor Interacting Protein Kinase 3 (RIPK3) has a key role in TNF-induced necroptosis. Here, the authors combine solid state NMR measurements, MD simulations and cell based assays to characterize mouse RIPK3 and they present the structure of the RIPK3 amyloid core.

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Autores principales: Xia-lian Wu, Hong Hu, Xing-qi Dong, Jing Zhang, Jian Wang, Charles D. Schwieters, Jing Liu, Guo-xiang Wu, Bing Li, Jing-yu Lin, Hua-yi Wang, Jun-xia Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/446eaf68a95446b2b5bed797c3cf78f3
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spelling oai:doaj.org-article:446eaf68a95446b2b5bed797c3cf78f32021-12-02T13:16:18ZThe amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis10.1038/s41467-021-21881-22041-1723https://doaj.org/article/446eaf68a95446b2b5bed797c3cf78f32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21881-2https://doaj.org/toc/2041-1723Receptor Interacting Protein Kinase 3 (RIPK3) has a key role in TNF-induced necroptosis. Here, the authors combine solid state NMR measurements, MD simulations and cell based assays to characterize mouse RIPK3 and they present the structure of the RIPK3 amyloid core.Xia-lian WuHong HuXing-qi DongJing ZhangJian WangCharles D. SchwietersJing LiuGuo-xiang WuBing LiJing-yu LinHua-yi WangJun-xia LuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xia-lian Wu
Hong Hu
Xing-qi Dong
Jing Zhang
Jian Wang
Charles D. Schwieters
Jing Liu
Guo-xiang Wu
Bing Li
Jing-yu Lin
Hua-yi Wang
Jun-xia Lu
The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis
description Receptor Interacting Protein Kinase 3 (RIPK3) has a key role in TNF-induced necroptosis. Here, the authors combine solid state NMR measurements, MD simulations and cell based assays to characterize mouse RIPK3 and they present the structure of the RIPK3 amyloid core.
format article
author Xia-lian Wu
Hong Hu
Xing-qi Dong
Jing Zhang
Jian Wang
Charles D. Schwieters
Jing Liu
Guo-xiang Wu
Bing Li
Jing-yu Lin
Hua-yi Wang
Jun-xia Lu
author_facet Xia-lian Wu
Hong Hu
Xing-qi Dong
Jing Zhang
Jian Wang
Charles D. Schwieters
Jing Liu
Guo-xiang Wu
Bing Li
Jing-yu Lin
Hua-yi Wang
Jun-xia Lu
author_sort Xia-lian Wu
title The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis
title_short The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis
title_full The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis
title_fullStr The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis
title_full_unstemmed The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis
title_sort amyloid structure of mouse ripk3 (receptor interacting protein kinase 3) in cell necroptosis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/446eaf68a95446b2b5bed797c3cf78f3
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