SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care
Here the authors use RT-qPCR and mass spectrometry to analyze longitudinal blood samples from intensive care unit (ICU) COVID-19 patients and controls. They find that viral RNA and pentraxin-3 predict 28-day ICU mortality and that galectin-3-binding protein is an interaction partner of SARS-CoV-2 sp...
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Nature Portfolio
2021
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oai:doaj.org-article:4473e05193134fe3b894751bffb9a0622021-12-02T18:06:24ZSARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care10.1038/s41467-021-23494-12041-1723https://doaj.org/article/4473e05193134fe3b894751bffb9a0622021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23494-1https://doaj.org/toc/2041-1723Here the authors use RT-qPCR and mass spectrometry to analyze longitudinal blood samples from intensive care unit (ICU) COVID-19 patients and controls. They find that viral RNA and pentraxin-3 predict 28-day ICU mortality and that galectin-3-binding protein is an interaction partner of SARS-CoV-2 spike glycoprotein with antiviral properties.Clemens GutmannKaloyan TakovSean A. BurnapBhawana SinghHashim AliKonstantinos TheofilatosElla ReedMaria HasmanAdam NabeebaccusMatthew FishMark JW. McPhailKevin O’GallagherLukas E. SchmidtChristian CasselMarieke RienksXiaoke YinGeorg AuzingerSalvatore NapoliSalma F. MujibFrancesca TrovatoBarnaby SandersonBlair MerrickUmar NiaziMansoor SaqiKonstantina DimitrakopoulouRafael Fernández-LeiroSilke BraunRomy Kronstein-WiedemannKatie J. DooresJonathan D. EdgeworthAjay M. ShahStefan R. BornsteinTorsten TonnAdrian C. HaydayMauro GiaccaManu Shankar-HariManuel MayrNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
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DOAJ |
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DOAJ |
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Science Q Clemens Gutmann Kaloyan Takov Sean A. Burnap Bhawana Singh Hashim Ali Konstantinos Theofilatos Ella Reed Maria Hasman Adam Nabeebaccus Matthew Fish Mark JW. McPhail Kevin O’Gallagher Lukas E. Schmidt Christian Cassel Marieke Rienks Xiaoke Yin Georg Auzinger Salvatore Napoli Salma F. Mujib Francesca Trovato Barnaby Sanderson Blair Merrick Umar Niazi Mansoor Saqi Konstantina Dimitrakopoulou Rafael Fernández-Leiro Silke Braun Romy Kronstein-Wiedemann Katie J. Doores Jonathan D. Edgeworth Ajay M. Shah Stefan R. Bornstein Torsten Tonn Adrian C. Hayday Mauro Giacca Manu Shankar-Hari Manuel Mayr SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care |
| description |
Here the authors use RT-qPCR and mass spectrometry to analyze longitudinal blood samples from intensive care unit (ICU) COVID-19 patients and controls. They find that viral RNA and pentraxin-3 predict 28-day ICU mortality and that galectin-3-binding protein is an interaction partner of SARS-CoV-2 spike glycoprotein with antiviral properties. |
| format |
article |
| author |
Clemens Gutmann Kaloyan Takov Sean A. Burnap Bhawana Singh Hashim Ali Konstantinos Theofilatos Ella Reed Maria Hasman Adam Nabeebaccus Matthew Fish Mark JW. McPhail Kevin O’Gallagher Lukas E. Schmidt Christian Cassel Marieke Rienks Xiaoke Yin Georg Auzinger Salvatore Napoli Salma F. Mujib Francesca Trovato Barnaby Sanderson Blair Merrick Umar Niazi Mansoor Saqi Konstantina Dimitrakopoulou Rafael Fernández-Leiro Silke Braun Romy Kronstein-Wiedemann Katie J. Doores Jonathan D. Edgeworth Ajay M. Shah Stefan R. Bornstein Torsten Tonn Adrian C. Hayday Mauro Giacca Manu Shankar-Hari Manuel Mayr |
| author_facet |
Clemens Gutmann Kaloyan Takov Sean A. Burnap Bhawana Singh Hashim Ali Konstantinos Theofilatos Ella Reed Maria Hasman Adam Nabeebaccus Matthew Fish Mark JW. McPhail Kevin O’Gallagher Lukas E. Schmidt Christian Cassel Marieke Rienks Xiaoke Yin Georg Auzinger Salvatore Napoli Salma F. Mujib Francesca Trovato Barnaby Sanderson Blair Merrick Umar Niazi Mansoor Saqi Konstantina Dimitrakopoulou Rafael Fernández-Leiro Silke Braun Romy Kronstein-Wiedemann Katie J. Doores Jonathan D. Edgeworth Ajay M. Shah Stefan R. Bornstein Torsten Tonn Adrian C. Hayday Mauro Giacca Manu Shankar-Hari Manuel Mayr |
| author_sort |
Clemens Gutmann |
| title |
SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care |
| title_short |
SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care |
| title_full |
SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care |
| title_fullStr |
SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care |
| title_full_unstemmed |
SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care |
| title_sort |
sars-cov-2 rnaemia and proteomic trajectories inform prognostication in covid-19 patients admitted to intensive care |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/4473e05193134fe3b894751bffb9a062 |
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