Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres

Cellular contractility is regulated by the GTPase RhoA, but how local signals are translated to a cell-level response is not known. Here the authors show that targeted RhoA activation results in propagation of force along stress fibres and actin flow, and identify zyxin as a regulator of stress fibr...

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Bibliographic Details
Main Authors: Patrick W. Oakes, Elizabeth Wagner, Christoph A. Brand, Dimitri Probst, Marco Linke, Ulrich S. Schwarz, Michael Glotzer, Margaret L. Gardel
Format: article
Language:EN
Published: Nature Portfolio 2017
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Online Access:https://doaj.org/article/447431f6514b4d158ce8bc4408d48bfd
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