Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres

Cellular contractility is regulated by the GTPase RhoA, but how local signals are translated to a cell-level response is not known. Here the authors show that targeted RhoA activation results in propagation of force along stress fibres and actin flow, and identify zyxin as a regulator of stress fibr...

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Autores principales:	Patrick W. Oakes, Elizabeth Wagner, Christoph A. Brand, Dimitri Probst, Marco Linke, Ulrich S. Schwarz, Michael Glotzer, Margaret L. Gardel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/447431f6514b4d158ce8bc4408d48bfd
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spelling	oai:doaj.org-article:447431f6514b4d158ce8bc4408d48bfd2021-12-02T15:38:35ZOptogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres10.1038/ncomms158172041-1723https://doaj.org/article/447431f6514b4d158ce8bc4408d48bfd2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15817https://doaj.org/toc/2041-1723Cellular contractility is regulated by the GTPase RhoA, but how local signals are translated to a cell-level response is not known. Here the authors show that targeted RhoA activation results in propagation of force along stress fibres and actin flow, and identify zyxin as a regulator of stress fibre mechanics and homeostasis.Patrick W. OakesElizabeth WagnerChristoph A. BrandDimitri ProbstMarco LinkeUlrich S. SchwarzMichael GlotzerMargaret L. GardelNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patrick W. Oakes Elizabeth Wagner Christoph A. Brand Dimitri Probst Marco Linke Ulrich S. Schwarz Michael Glotzer Margaret L. Gardel Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres
description	Cellular contractility is regulated by the GTPase RhoA, but how local signals are translated to a cell-level response is not known. Here the authors show that targeted RhoA activation results in propagation of force along stress fibres and actin flow, and identify zyxin as a regulator of stress fibre mechanics and homeostasis.
format	article
author	Patrick W. Oakes Elizabeth Wagner Christoph A. Brand Dimitri Probst Marco Linke Ulrich S. Schwarz Michael Glotzer Margaret L. Gardel
author_facet	Patrick W. Oakes Elizabeth Wagner Christoph A. Brand Dimitri Probst Marco Linke Ulrich S. Schwarz Michael Glotzer Margaret L. Gardel
author_sort	Patrick W. Oakes
title	Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres
title_short	Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres
title_full	Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres
title_fullStr	Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres
title_full_unstemmed	Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres
title_sort	optogenetic control of rhoa reveals zyxin-mediated elasticity of stress fibres
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/447431f6514b4d158ce8bc4408d48bfd
work_keys_str_mv	AT patrickwoakes optogeneticcontrolofrhoarevealszyxinmediatedelasticityofstressfibres AT elizabethwagner optogeneticcontrolofrhoarevealszyxinmediatedelasticityofstressfibres AT christophabrand optogeneticcontrolofrhoarevealszyxinmediatedelasticityofstressfibres AT dimitriprobst optogeneticcontrolofrhoarevealszyxinmediatedelasticityofstressfibres AT marcolinke optogeneticcontrolofrhoarevealszyxinmediatedelasticityofstressfibres AT ulrichsschwarz optogeneticcontrolofrhoarevealszyxinmediatedelasticityofstressfibres AT michaelglotzer optogeneticcontrolofrhoarevealszyxinmediatedelasticityofstressfibres AT margaretlgardel optogeneticcontrolofrhoarevealszyxinmediatedelasticityofstressfibres
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Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres

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