Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire

Longevity of antibody responses has been attributed to persistence of plasma cells in mice. Here the authors provide human data in support of this model by immunoglobulin sequencing bone marrow sections from two human donors over 6.5 years to show temporal stability of plasma cell clonotypes, but no...

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Autores principales: Gabriel C. Wu, Nai-Kong V. Cheung, George Georgiou, Edward M. Marcotte, Gregory C. Ippolito
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/447cc22a60744caf9e90092f81c65355
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