Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire

Longevity of antibody responses has been attributed to persistence of plasma cells in mice. Here the authors provide human data in support of this model by immunoglobulin sequencing bone marrow sections from two human donors over 6.5 years to show temporal stability of plasma cell clonotypes, but no...

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Autores principales:	Gabriel C. Wu, Nai-Kong V. Cheung, George Georgiou, Edward M. Marcotte, Gregory C. Ippolito
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/447cc22a60744caf9e90092f81c65355
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id	oai:doaj.org-article:447cc22a60744caf9e90092f81c65355
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spelling	oai:doaj.org-article:447cc22a60744caf9e90092f81c653552021-12-02T14:38:55ZTemporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire10.1038/ncomms138382041-1723https://doaj.org/article/447cc22a60744caf9e90092f81c653552016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13838https://doaj.org/toc/2041-1723Longevity of antibody responses has been attributed to persistence of plasma cells in mice. Here the authors provide human data in support of this model by immunoglobulin sequencing bone marrow sections from two human donors over 6.5 years to show temporal stability of plasma cell clonotypes, but not other B cells.Gabriel C. WuNai-Kong V. CheungGeorge GeorgiouEdward M. MarcotteGregory C. IppolitoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gabriel C. Wu Nai-Kong V. Cheung George Georgiou Edward M. Marcotte Gregory C. Ippolito Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire
description	Longevity of antibody responses has been attributed to persistence of plasma cells in mice. Here the authors provide human data in support of this model by immunoglobulin sequencing bone marrow sections from two human donors over 6.5 years to show temporal stability of plasma cell clonotypes, but not other B cells.
format	article
author	Gabriel C. Wu Nai-Kong V. Cheung George Georgiou Edward M. Marcotte Gregory C. Ippolito
author_facet	Gabriel C. Wu Nai-Kong V. Cheung George Georgiou Edward M. Marcotte Gregory C. Ippolito
author_sort	Gabriel C. Wu
title	Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire
title_short	Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire
title_full	Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire
title_fullStr	Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire
title_full_unstemmed	Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire
title_sort	temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/447cc22a60744caf9e90092f81c65355
work_keys_str_mv	AT gabrielcwu temporalstabilityandmolecularpersistenceofthebonemarrowplasmacellantibodyrepertoire AT naikongvcheung temporalstabilityandmolecularpersistenceofthebonemarrowplasmacellantibodyrepertoire AT georgegeorgiou temporalstabilityandmolecularpersistenceofthebonemarrowplasmacellantibodyrepertoire AT edwardmmarcotte temporalstabilityandmolecularpersistenceofthebonemarrowplasmacellantibodyrepertoire AT gregorycippolito temporalstabilityandmolecularpersistenceofthebonemarrowplasmacellantibodyrepertoire
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Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire

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