Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire
Longevity of antibody responses has been attributed to persistence of plasma cells in mice. Here the authors provide human data in support of this model by immunoglobulin sequencing bone marrow sections from two human donors over 6.5 years to show temporal stability of plasma cell clonotypes, but no...
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Auteurs principaux: | Gabriel C. Wu, Nai-Kong V. Cheung, George Georgiou, Edward M. Marcotte, Gregory C. Ippolito |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2016
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Accès en ligne: | https://doaj.org/article/447cc22a60744caf9e90092f81c65355 |
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