Zinc is a potent and specific inhibitor of IFN-λ3 signalling

Lambda interferons (IFNL) are involved in the immune response to viral infection. Here the authors show that zinc can interfere with IFNL signalling, and that in HCV patients the rs12979860 polymorphism regulates blood zinc levels and, subsequently, the hepatic immune response.

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Autores principales:	Scott A. Read, Kate S. O’Connor, Vijay Suppiah, Chantelle L. E. Ahlenstiel, Stephanie Obeid, Kristina M. Cook, Anthony Cunningham, Mark W. Douglas, Philip J. Hogg, David Booth, Jacob George, Golo Ahlenstiel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/448cc0a156b540329808e92d9913726d
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spelling	oai:doaj.org-article:448cc0a156b540329808e92d9913726d2021-12-02T14:40:37ZZinc is a potent and specific inhibitor of IFN-λ3 signalling10.1038/ncomms152452041-1723https://doaj.org/article/448cc0a156b540329808e92d9913726d2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15245https://doaj.org/toc/2041-1723Lambda interferons (IFNL) are involved in the immune response to viral infection. Here the authors show that zinc can interfere with IFNL signalling, and that in HCV patients the rs12979860 polymorphism regulates blood zinc levels and, subsequently, the hepatic immune response.Scott A. ReadKate S. O’ConnorVijay SuppiahChantelle L. E. AhlenstielStephanie ObeidKristina M. CookAnthony CunninghamMark W. DouglasPhilip J. HoggDavid BoothJacob GeorgeGolo AhlenstielNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Scott A. Read Kate S. O’Connor Vijay Suppiah Chantelle L. E. Ahlenstiel Stephanie Obeid Kristina M. Cook Anthony Cunningham Mark W. Douglas Philip J. Hogg David Booth Jacob George Golo Ahlenstiel Zinc is a potent and specific inhibitor of IFN-λ3 signalling
description	Lambda interferons (IFNL) are involved in the immune response to viral infection. Here the authors show that zinc can interfere with IFNL signalling, and that in HCV patients the rs12979860 polymorphism regulates blood zinc levels and, subsequently, the hepatic immune response.
format	article
author	Scott A. Read Kate S. O’Connor Vijay Suppiah Chantelle L. E. Ahlenstiel Stephanie Obeid Kristina M. Cook Anthony Cunningham Mark W. Douglas Philip J. Hogg David Booth Jacob George Golo Ahlenstiel
author_facet	Scott A. Read Kate S. O’Connor Vijay Suppiah Chantelle L. E. Ahlenstiel Stephanie Obeid Kristina M. Cook Anthony Cunningham Mark W. Douglas Philip J. Hogg David Booth Jacob George Golo Ahlenstiel
author_sort	Scott A. Read
title	Zinc is a potent and specific inhibitor of IFN-λ3 signalling
title_short	Zinc is a potent and specific inhibitor of IFN-λ3 signalling
title_full	Zinc is a potent and specific inhibitor of IFN-λ3 signalling
title_fullStr	Zinc is a potent and specific inhibitor of IFN-λ3 signalling
title_full_unstemmed	Zinc is a potent and specific inhibitor of IFN-λ3 signalling
title_sort	zinc is a potent and specific inhibitor of ifn-λ3 signalling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/448cc0a156b540329808e92d9913726d
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Zinc is a potent and specific inhibitor of IFN-λ3 signalling

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