The adaptive landscape of a metallo-enzyme is shaped by environment-dependent epistasis

The metaphor of an adaptive landscape is presented quantitatively by looking at molecular adaptations and their catalytic consequences in a recently evolved bacterial enzyme. The study identifies both genotype-by-environment interactions and environment-dependent epistasis as factors that can alter...

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Auteurs principaux: Dave W. Anderson, Florian Baier, Gloria Yang, Nobuhiko Tokuriki
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/44a0b8b6361c40a7b937ffbaa42ff7e2
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