Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6

Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6

The mechanism underlying endothelial cell responses to BMP signals is unknown. Here, the authors show that the endothelial response to pro-angiogenic BMP ligands is regulated by Notch via its effect on SMAD6, a known inhibitor of BMP intracellular signaling cascade.

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Detalles Bibliográficos
Autores principales: Kevin P. Mouillesseaux, David S. Wiley, Lauren M. Saunders, Lyndsay A. Wylie, Erich J. Kushner, Diana C. Chong, Kathryn M. Citrin, Andrew T. Barber, Youngsook Park, Jun-Dae Kim, Leigh Ann Samsa, Jongmin Kim, Jiandong Liu, Suk-Won Jin, Victoria L. Bautch
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/44b4ac900f6945ee9370e7b87a8009d9
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https://doaj.org/article/44b4ac900f6945ee9370e7b87a8009d9

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