Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6

The mechanism underlying endothelial cell responses to BMP signals is unknown. Here, the authors show that the endothelial response to pro-angiogenic BMP ligands is regulated by Notch via its effect on SMAD6, a known inhibitor of BMP intracellular signaling cascade.

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Autores principales:	Kevin P. Mouillesseaux, David S. Wiley, Lauren M. Saunders, Lyndsay A. Wylie, Erich J. Kushner, Diana C. Chong, Kathryn M. Citrin, Andrew T. Barber, Youngsook Park, Jun-Dae Kim, Leigh Ann Samsa, Jongmin Kim, Jiandong Liu, Suk-Won Jin, Victoria L. Bautch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/44b4ac900f6945ee9370e7b87a8009d9
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spelling	oai:doaj.org-article:44b4ac900f6945ee9370e7b87a8009d92021-12-02T17:31:18ZNotch regulates BMP responsiveness and lateral branching in vessel networks via SMAD610.1038/ncomms132472041-1723https://doaj.org/article/44b4ac900f6945ee9370e7b87a8009d92016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13247https://doaj.org/toc/2041-1723The mechanism underlying endothelial cell responses to BMP signals is unknown. Here, the authors show that the endothelial response to pro-angiogenic BMP ligands is regulated by Notch via its effect on SMAD6, a known inhibitor of BMP intracellular signaling cascade.Kevin P. MouillesseauxDavid S. WileyLauren M. SaundersLyndsay A. WylieErich J. KushnerDiana C. ChongKathryn M. CitrinAndrew T. BarberYoungsook ParkJun-Dae KimLeigh Ann SamsaJongmin KimJiandong LiuSuk-Won JinVictoria L. BautchNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kevin P. Mouillesseaux David S. Wiley Lauren M. Saunders Lyndsay A. Wylie Erich J. Kushner Diana C. Chong Kathryn M. Citrin Andrew T. Barber Youngsook Park Jun-Dae Kim Leigh Ann Samsa Jongmin Kim Jiandong Liu Suk-Won Jin Victoria L. Bautch Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6
description	The mechanism underlying endothelial cell responses to BMP signals is unknown. Here, the authors show that the endothelial response to pro-angiogenic BMP ligands is regulated by Notch via its effect on SMAD6, a known inhibitor of BMP intracellular signaling cascade.
format	article
author	Kevin P. Mouillesseaux David S. Wiley Lauren M. Saunders Lyndsay A. Wylie Erich J. Kushner Diana C. Chong Kathryn M. Citrin Andrew T. Barber Youngsook Park Jun-Dae Kim Leigh Ann Samsa Jongmin Kim Jiandong Liu Suk-Won Jin Victoria L. Bautch
author_facet	Kevin P. Mouillesseaux David S. Wiley Lauren M. Saunders Lyndsay A. Wylie Erich J. Kushner Diana C. Chong Kathryn M. Citrin Andrew T. Barber Youngsook Park Jun-Dae Kim Leigh Ann Samsa Jongmin Kim Jiandong Liu Suk-Won Jin Victoria L. Bautch
author_sort	Kevin P. Mouillesseaux
title	Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6
title_short	Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6
title_full	Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6
title_fullStr	Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6
title_full_unstemmed	Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6
title_sort	notch regulates bmp responsiveness and lateral branching in vessel networks via smad6
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/44b4ac900f6945ee9370e7b87a8009d9
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Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6

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