HIV and mature dendritic cells: Trojan exosomes riding the Trojan horse?

Exosomes are secreted cellular vesicles that can induce specific CD4(+) T cell responses in vivo when they interact with competent antigen-presenting cells like mature dendritic cells (mDCs). The Trojan exosome hypothesis proposes that retroviruses can take advantage of the cell-encoded intercellula...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nuria Izquierdo-Useros, Mar Naranjo-Gómez, Itziar Erkizia, Maria Carmen Puertas, Francesc E Borràs, Julià Blanco, Javier Martinez-Picado
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/44b7853429764e1390f264bef1ff14e5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:44b7853429764e1390f264bef1ff14e5
record_format	dspace
spelling	oai:doaj.org-article:44b7853429764e1390f264bef1ff14e52021-11-25T05:48:13ZHIV and mature dendritic cells: Trojan exosomes riding the Trojan horse?1553-73661553-737410.1371/journal.ppat.1000740https://doaj.org/article/44b7853429764e1390f264bef1ff14e52010-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20360840/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Exosomes are secreted cellular vesicles that can induce specific CD4(+) T cell responses in vivo when they interact with competent antigen-presenting cells like mature dendritic cells (mDCs). The Trojan exosome hypothesis proposes that retroviruses can take advantage of the cell-encoded intercellular vesicle traffic and exosome exchange pathway, moving between cells in the absence of fusion events in search of adequate target cells. Here, we discuss recent data supporting this hypothesis, which further explains how DCs can capture and internalize retroviruses like HIV-1 in the absence of fusion events, leading to the productive infection of interacting CD4(+) T cells and contributing to viral spread through a mechanism known as trans-infection. We suggest that HIV-1 can exploit an exosome antigen-dissemination pathway intrinsic to mDCs, allowing viral internalization and final trans-infection of CD4(+) T cells. In contrast to previous reports that focus on the ability of immature DCs to capture HIV in the mucosa, this review emphasizes the outstanding role that mature DCs could have promoting trans-infection in the lymph node, underscoring a new potential viral dissemination pathway.Nuria Izquierdo-UserosMar Naranjo-GómezItziar ErkiziaMaria Carmen PuertasFrancesc E BorràsJulià BlancoJavier Martinez-PicadoPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 6, Iss 3, p e1000740 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Nuria Izquierdo-Useros Mar Naranjo-Gómez Itziar Erkizia Maria Carmen Puertas Francesc E Borràs Julià Blanco Javier Martinez-Picado HIV and mature dendritic cells: Trojan exosomes riding the Trojan horse?
description	Exosomes are secreted cellular vesicles that can induce specific CD4(+) T cell responses in vivo when they interact with competent antigen-presenting cells like mature dendritic cells (mDCs). The Trojan exosome hypothesis proposes that retroviruses can take advantage of the cell-encoded intercellular vesicle traffic and exosome exchange pathway, moving between cells in the absence of fusion events in search of adequate target cells. Here, we discuss recent data supporting this hypothesis, which further explains how DCs can capture and internalize retroviruses like HIV-1 in the absence of fusion events, leading to the productive infection of interacting CD4(+) T cells and contributing to viral spread through a mechanism known as trans-infection. We suggest that HIV-1 can exploit an exosome antigen-dissemination pathway intrinsic to mDCs, allowing viral internalization and final trans-infection of CD4(+) T cells. In contrast to previous reports that focus on the ability of immature DCs to capture HIV in the mucosa, this review emphasizes the outstanding role that mature DCs could have promoting trans-infection in the lymph node, underscoring a new potential viral dissemination pathway.
format	article
author	Nuria Izquierdo-Useros Mar Naranjo-Gómez Itziar Erkizia Maria Carmen Puertas Francesc E Borràs Julià Blanco Javier Martinez-Picado
author_facet	Nuria Izquierdo-Useros Mar Naranjo-Gómez Itziar Erkizia Maria Carmen Puertas Francesc E Borràs Julià Blanco Javier Martinez-Picado
author_sort	Nuria Izquierdo-Useros
title	HIV and mature dendritic cells: Trojan exosomes riding the Trojan horse?
title_short	HIV and mature dendritic cells: Trojan exosomes riding the Trojan horse?
title_full	HIV and mature dendritic cells: Trojan exosomes riding the Trojan horse?
title_fullStr	HIV and mature dendritic cells: Trojan exosomes riding the Trojan horse?
title_full_unstemmed	HIV and mature dendritic cells: Trojan exosomes riding the Trojan horse?
title_sort	hiv and mature dendritic cells: trojan exosomes riding the trojan horse?
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/44b7853429764e1390f264bef1ff14e5
work_keys_str_mv	AT nuriaizquierdouseros hivandmaturedendriticcellstrojanexosomesridingthetrojanhorse AT marnaranjogomez hivandmaturedendriticcellstrojanexosomesridingthetrojanhorse AT itziarerkizia hivandmaturedendriticcellstrojanexosomesridingthetrojanhorse AT mariacarmenpuertas hivandmaturedendriticcellstrojanexosomesridingthetrojanhorse AT francesceborras hivandmaturedendriticcellstrojanexosomesridingthetrojanhorse AT juliablanco hivandmaturedendriticcellstrojanexosomesridingthetrojanhorse AT javiermartinezpicado hivandmaturedendriticcellstrojanexosomesridingthetrojanhorse
_version_	1718414454720299008

HIV and mature dendritic cells: Trojan exosomes riding the Trojan horse?

Ejemplares similares