Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity

Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity

Abstract The expression and function of some xenobiotic transporters varies according to the time of day, causing the dosing time-dependent changes in drug disposition and toxicity. Multidrug resistance-associated protein-4 (MRP4), an ATP­binding cassette (ABC) efflux transporter encoded by the Abcc...

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Détails bibliographiques
Auteurs principaux: Mizuki Kato, Yuya Tsurudome, Takumi Kanemitsu, Sai Yasukochi, Yuki Kanado, Takashi Ogino, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo
Format: article
Langue:EN
Publié: Nature Portfolio 2020
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/44bf9c4e2baa4bbdb723542927ad3ac6
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https://doaj.org/article/44bf9c4e2baa4bbdb723542927ad3ac6

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