PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

Inflammation involves a Warburg effect that switches cellular metabolism to glycolysis. Here the authors show this switch drives IL-1β, IL-18 and HMGB1 release from macrophages by activating the NLRP3 and AIM2 inflammasomes via protein kinase R phosphorylation, a pathway that can be inhibited to pre...

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Bibliographic Details
Main Authors: Min Xie, Yan Yu, Rui Kang, Shan Zhu, Liangchun Yang, Ling Zeng, Xiaofang Sun, Minghua Yang, Timothy R. Billiar, Haichao Wang, Lizhi Cao, Jianxin Jiang, Daolin Tang
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
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Online Access:https://doaj.org/article/44e902eea61c43bbab9d4975480e57e9
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