Conformational changes in acetylcholine binding protein investigated by temperature accelerated molecular dynamics.

Despite the large number of studies available on nicotinic acetylcholine receptors, a complete account of the mechanistic aspects of their gating transition in response to ligand binding still remains elusive. As a first step toward dissecting the transition mechanism by accelerated sampling techniq...

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Autores principales: Zeynab Mohammad Hosseini Naveh, Therese E Malliavin, Luca Maragliano, Grazia Cottone, Giovanni Ciccotti
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/44f37191074c46c2b4b5cd534581a205
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