Intravenous grafts of amniotic fluid-derived stem cells induce endogenous cell proliferation and attenuate behavioral deficits in ischemic stroke rats.

Intravenous grafts of amniotic fluid-derived stem cells induce endogenous cell proliferation and attenuate behavioral deficits in ischemic stroke rats.

We recently reported isolation of viable rat amniotic fluid-derived stem (AFS) cells [1]. Here, we tested the therapeutic benefits of AFS cells in a rodent model of ischemic stroke. Adult male Sprague-Dawley rats received a 60-minute middle cerebral artery occlusion (MCAo). Thirty-five days later, a...

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Main Authors: Naoki Tajiri, Sandra Acosta, Loren E Glover, Paula C Bickford, Alejandra Jacotte Simancas, Takao Yasuhara, Isao Date, Marianna A Solomita, Ivana Antonucci, Liborio Stuppia, Yuji Kaneko, Cesar V Borlongan
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/4510cf031aa14026913dfb25bd1eb228
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https://doaj.org/article/4510cf031aa14026913dfb25bd1eb228

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