The GPR171 pathway suppresses T cell activation and limits antitumor immunity

Proliferative and effector functions of T cells are determined by T cell receptor signalling and modulated by activator and inhibitory co-receptors. Authors report here that the G-protein-coupled receptor GPR171 functions as a co-inhibitor of T cell signalling and might serve as a target for cancer...

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Autores principales:	Yuki Fujiwara, Robert J. Torphy, Yi Sun, Emily N. Miller, Felix Ho, Nicholas Borcherding, Tuoqi Wu, Raul M. Torres, Weizhou Zhang, Richard D. Schulick, Yuwen Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4515b28636ca4c3b83d2b6c3169e1d1a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:4515b28636ca4c3b83d2b6c3169e1d1a2021-12-02T16:56:43ZThe GPR171 pathway suppresses T cell activation and limits antitumor immunity10.1038/s41467-021-26135-92041-1723https://doaj.org/article/4515b28636ca4c3b83d2b6c3169e1d1a2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26135-9https://doaj.org/toc/2041-1723Proliferative and effector functions of T cells are determined by T cell receptor signalling and modulated by activator and inhibitory co-receptors. Authors report here that the G-protein-coupled receptor GPR171 functions as a co-inhibitor of T cell signalling and might serve as a target for cancer immunotherapy.Yuki FujiwaraRobert J. TorphyYi SunEmily N. MillerFelix HoNicholas BorcherdingTuoqi WuRaul M. TorresWeizhou ZhangRichard D. SchulickYuwen ZhuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuki Fujiwara Robert J. Torphy Yi Sun Emily N. Miller Felix Ho Nicholas Borcherding Tuoqi Wu Raul M. Torres Weizhou Zhang Richard D. Schulick Yuwen Zhu The GPR171 pathway suppresses T cell activation and limits antitumor immunity
description	Proliferative and effector functions of T cells are determined by T cell receptor signalling and modulated by activator and inhibitory co-receptors. Authors report here that the G-protein-coupled receptor GPR171 functions as a co-inhibitor of T cell signalling and might serve as a target for cancer immunotherapy.
format	article
author	Yuki Fujiwara Robert J. Torphy Yi Sun Emily N. Miller Felix Ho Nicholas Borcherding Tuoqi Wu Raul M. Torres Weizhou Zhang Richard D. Schulick Yuwen Zhu
author_facet	Yuki Fujiwara Robert J. Torphy Yi Sun Emily N. Miller Felix Ho Nicholas Borcherding Tuoqi Wu Raul M. Torres Weizhou Zhang Richard D. Schulick Yuwen Zhu
author_sort	Yuki Fujiwara
title	The GPR171 pathway suppresses T cell activation and limits antitumor immunity
title_short	The GPR171 pathway suppresses T cell activation and limits antitumor immunity
title_full	The GPR171 pathway suppresses T cell activation and limits antitumor immunity
title_fullStr	The GPR171 pathway suppresses T cell activation and limits antitumor immunity
title_full_unstemmed	The GPR171 pathway suppresses T cell activation and limits antitumor immunity
title_sort	gpr171 pathway suppresses t cell activation and limits antitumor immunity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4515b28636ca4c3b83d2b6c3169e1d1a
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The GPR171 pathway suppresses T cell activation and limits antitumor immunity

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