How RNA transcripts coordinate DNA recombination and repair

How RNA transcripts coordinate DNA recombination and repair

Homologous recombination (HR) typically uses DNA as a donor template to accurately repair DNA breaks. Here, the authors elucidate two mechanisms by which RAD52 uses RNA as a template for HR: one involving RNA-mediated synapsis of a homologous DNA break, and the other involving reverse transcriptase...

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Autores principales: Shane McDevitt, Timur Rusanov, Tatiana Kent, Gurushankar Chandramouly, Richard T. Pomerantz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/451d01082cb64f63ab8102cbd1ccb3ed
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spelling oai:doaj.org-article:451d01082cb64f63ab8102cbd1ccb3ed2021-12-02T16:50:05ZHow RNA transcripts coordinate DNA recombination and repair10.1038/s41467-018-03483-72041-1723https://doaj.org/article/451d01082cb64f63ab8102cbd1ccb3ed2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03483-7https://doaj.org/toc/2041-1723Homologous recombination (HR) typically uses DNA as a donor template to accurately repair DNA breaks. Here, the authors elucidate two mechanisms by which RAD52 uses RNA as a template for HR: one involving RNA-mediated synapsis of a homologous DNA break, and the other involving reverse transcriptase dependent RNA-to-DNA sequence transfer at DNA breaks.Shane McDevittTimur RusanovTatiana KentGurushankar ChandramoulyRichard T. PomerantzNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shane McDevitt
Timur Rusanov
Tatiana Kent
Gurushankar Chandramouly
Richard T. Pomerantz
How RNA transcripts coordinate DNA recombination and repair
description Homologous recombination (HR) typically uses DNA as a donor template to accurately repair DNA breaks. Here, the authors elucidate two mechanisms by which RAD52 uses RNA as a template for HR: one involving RNA-mediated synapsis of a homologous DNA break, and the other involving reverse transcriptase dependent RNA-to-DNA sequence transfer at DNA breaks.
format article
author Shane McDevitt
Timur Rusanov
Tatiana Kent
Gurushankar Chandramouly
Richard T. Pomerantz
author_facet Shane McDevitt
Timur Rusanov
Tatiana Kent
Gurushankar Chandramouly
Richard T. Pomerantz
author_sort Shane McDevitt
title How RNA transcripts coordinate DNA recombination and repair
title_short How RNA transcripts coordinate DNA recombination and repair
title_full How RNA transcripts coordinate DNA recombination and repair
title_fullStr How RNA transcripts coordinate DNA recombination and repair
title_full_unstemmed How RNA transcripts coordinate DNA recombination and repair
title_sort how rna transcripts coordinate dna recombination and repair
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/451d01082cb64f63ab8102cbd1ccb3ed
work_keys_str_mv AT shanemcdevitt howrnatranscriptscoordinatednarecombinationandrepair
AT timurrusanov howrnatranscriptscoordinatednarecombinationandrepair
AT tatianakent howrnatranscriptscoordinatednarecombinationandrepair
AT gurushankarchandramouly howrnatranscriptscoordinatednarecombinationandrepair
AT richardtpomerantz howrnatranscriptscoordinatednarecombinationandrepair
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