Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection

Therapeutic antibodies against flaviviruses often promote neutralization by targeting the envelope protein of the virion. However, this approach is hindered by a possible concern for antibody-dependent enhancement of infection and paradoxical worsening of disease.

Guardado en:

Detalles Bibliográficos
Autores principales:	Alex W. Wessel, Michael P. Doyle, Taylor B. Engdahl, Jessica Rodriguez, James E. Crowe, Michael S. Diamond
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/452803504505489b8c84cd953cbd6230
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:452803504505489b8c84cd953cbd6230
record_format	dspace
spelling	oai:doaj.org-article:452803504505489b8c84cd953cbd62302021-11-03T21:52:35ZHuman Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection2150-751110.1128/mBio.02440-21https://doaj.org/article/452803504505489b8c84cd953cbd62302021-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02440-21https://doaj.org/toc/2150-7511 Therapeutic antibodies against flaviviruses often promote neutralization by targeting the envelope protein of the virion. However, this approach is hindered by a possible concern for antibody-dependent enhancement of infection and paradoxical worsening of disease.Alex W. WesselMichael P. DoyleTaylor B. EngdahlJessica RodriguezJames E. CroweMichael S. DiamondAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Alex W. Wessel Michael P. Doyle Taylor B. Engdahl Jessica Rodriguez James E. Crowe Michael S. Diamond Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection
description	Therapeutic antibodies against flaviviruses often promote neutralization by targeting the envelope protein of the virion. However, this approach is hindered by a possible concern for antibody-dependent enhancement of infection and paradoxical worsening of disease.
format	article
author	Alex W. Wessel Michael P. Doyle Taylor B. Engdahl Jessica Rodriguez James E. Crowe Michael S. Diamond
author_facet	Alex W. Wessel Michael P. Doyle Taylor B. Engdahl Jessica Rodriguez James E. Crowe Michael S. Diamond
author_sort	Alex W. Wessel
title	Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection
title_short	Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection
title_full	Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection
title_fullStr	Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection
title_full_unstemmed	Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection
title_sort	human monoclonal antibodies against ns1 protein protect against lethal west nile virus infection
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/452803504505489b8c84cd953cbd6230
work_keys_str_mv	AT alexwwessel humanmonoclonalantibodiesagainstns1proteinprotectagainstlethalwestnilevirusinfection AT michaelpdoyle humanmonoclonalantibodiesagainstns1proteinprotectagainstlethalwestnilevirusinfection AT taylorbengdahl humanmonoclonalantibodiesagainstns1proteinprotectagainstlethalwestnilevirusinfection AT jessicarodriguez humanmonoclonalantibodiesagainstns1proteinprotectagainstlethalwestnilevirusinfection AT jamesecrowe humanmonoclonalantibodiesagainstns1proteinprotectagainstlethalwestnilevirusinfection AT michaelsdiamond humanmonoclonalantibodiesagainstns1proteinprotectagainstlethalwestnilevirusinfection
_version_	1718445391552184320

Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection

Ejemplares similares