IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro
IFITM proteins can inhibit several viruses, but effects on SARS-CoV-2 infection are not well understood. Here, the authors show that endogenous IFITMs support SARS-CoV-2 infection in different in vitro models by binding spike and enhancing virus entry.
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Nature Portfolio
2021
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oai:doaj.org-article:45486c77950d4620853ea7ad4237e6002021-12-02T16:14:24ZIFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro10.1038/s41467-021-24817-y2041-1723https://doaj.org/article/45486c77950d4620853ea7ad4237e6002021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24817-yhttps://doaj.org/toc/2041-1723IFITM proteins can inhibit several viruses, but effects on SARS-CoV-2 infection are not well understood. Here, the authors show that endogenous IFITMs support SARS-CoV-2 infection in different in vitro models by binding spike and enhancing virus entry.Caterina Prelli BozzoRayhane NchiouaMeta VolcicLennart KoepkeJana KrügerDesiree SchützSandra HellerChristina M. StürzelDorota KmiecCarina ConzelmannJanis MüllerFabian ZechElisabeth BraunRüdiger GroßLukas WettsteinTatjana WeilJohanna WeißFederica DiofanoArmando A. Rodríguez AlfonsoSebastian WieseDaniel SauterJan MünchChristine GoffinetAlberto CataneseMichael SchönTobias M. BoeckersSteffen StengerKei SatoSteffen JustAlexander KlegerKonstantin M. J. SparrerFrank KirchhoffNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Caterina Prelli Bozzo Rayhane Nchioua Meta Volcic Lennart Koepke Jana Krüger Desiree Schütz Sandra Heller Christina M. Stürzel Dorota Kmiec Carina Conzelmann Janis Müller Fabian Zech Elisabeth Braun Rüdiger Groß Lukas Wettstein Tatjana Weil Johanna Weiß Federica Diofano Armando A. Rodríguez Alfonso Sebastian Wiese Daniel Sauter Jan Münch Christine Goffinet Alberto Catanese Michael Schön Tobias M. Boeckers Steffen Stenger Kei Sato Steffen Just Alexander Kleger Konstantin M. J. Sparrer Frank Kirchhoff IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro |
| description |
IFITM proteins can inhibit several viruses, but effects on SARS-CoV-2 infection are not well understood. Here, the authors show that endogenous IFITMs support SARS-CoV-2 infection in different in vitro models by binding spike and enhancing virus entry. |
| format |
article |
| author |
Caterina Prelli Bozzo Rayhane Nchioua Meta Volcic Lennart Koepke Jana Krüger Desiree Schütz Sandra Heller Christina M. Stürzel Dorota Kmiec Carina Conzelmann Janis Müller Fabian Zech Elisabeth Braun Rüdiger Groß Lukas Wettstein Tatjana Weil Johanna Weiß Federica Diofano Armando A. Rodríguez Alfonso Sebastian Wiese Daniel Sauter Jan Münch Christine Goffinet Alberto Catanese Michael Schön Tobias M. Boeckers Steffen Stenger Kei Sato Steffen Just Alexander Kleger Konstantin M. J. Sparrer Frank Kirchhoff |
| author_facet |
Caterina Prelli Bozzo Rayhane Nchioua Meta Volcic Lennart Koepke Jana Krüger Desiree Schütz Sandra Heller Christina M. Stürzel Dorota Kmiec Carina Conzelmann Janis Müller Fabian Zech Elisabeth Braun Rüdiger Groß Lukas Wettstein Tatjana Weil Johanna Weiß Federica Diofano Armando A. Rodríguez Alfonso Sebastian Wiese Daniel Sauter Jan Münch Christine Goffinet Alberto Catanese Michael Schön Tobias M. Boeckers Steffen Stenger Kei Sato Steffen Just Alexander Kleger Konstantin M. J. Sparrer Frank Kirchhoff |
| author_sort |
Caterina Prelli Bozzo |
| title |
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro |
| title_short |
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro |
| title_full |
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro |
| title_fullStr |
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro |
| title_full_unstemmed |
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro |
| title_sort |
ifitm proteins promote sars-cov-2 infection and are targets for virus inhibition in vitro |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/45486c77950d4620853ea7ad4237e600 |
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