mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2
The protein raptor is a subunit of the mTORC signalling complex. Here the authors show that Raptor also exists in a free form, unbound to mTORC, and that this free Raptor negatively regulates hepatic Akt activity and lipid metabolism in mice via a mechanism involving the Akt phosphatase PHLPP2.
Enregistré dans:
| Auteurs principaux: | , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2016
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/4557982e90754044bc5dda4f28d8a993 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|