mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2

The protein raptor is a subunit of the mTORC signalling complex. Here the authors show that Raptor also exists in a free form, unbound to mTORC, and that this free Raptor negatively regulates hepatic Akt activity and lipid metabolism in mice via a mechanism involving the Akt phosphatase PHLPP2.

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Autores principales:	KyeongJin Kim, Li Qiang, Matthew S. Hayden, David P. Sparling, Nicole H. Purcell, Utpal B. Pajvani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4557982e90754044bc5dda4f28d8a993
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spelling	oai:doaj.org-article:4557982e90754044bc5dda4f28d8a9932021-12-02T16:49:26ZmTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP210.1038/ncomms102552041-1723https://doaj.org/article/4557982e90754044bc5dda4f28d8a9932016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10255https://doaj.org/toc/2041-1723The protein raptor is a subunit of the mTORC signalling complex. Here the authors show that Raptor also exists in a free form, unbound to mTORC, and that this free Raptor negatively regulates hepatic Akt activity and lipid metabolism in mice via a mechanism involving the Akt phosphatase PHLPP2.KyeongJin KimLi QiangMatthew S. HaydenDavid P. SparlingNicole H. PurcellUtpal B. PajvaniNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q KyeongJin Kim Li Qiang Matthew S. Hayden David P. Sparling Nicole H. Purcell Utpal B. Pajvani mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2
description	The protein raptor is a subunit of the mTORC signalling complex. Here the authors show that Raptor also exists in a free form, unbound to mTORC, and that this free Raptor negatively regulates hepatic Akt activity and lipid metabolism in mice via a mechanism involving the Akt phosphatase PHLPP2.
format	article
author	KyeongJin Kim Li Qiang Matthew S. Hayden David P. Sparling Nicole H. Purcell Utpal B. Pajvani
author_facet	KyeongJin Kim Li Qiang Matthew S. Hayden David P. Sparling Nicole H. Purcell Utpal B. Pajvani
author_sort	KyeongJin Kim
title	mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2
title_short	mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2
title_full	mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2
title_fullStr	mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2
title_full_unstemmed	mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2
title_sort	mtorc1-independent raptor prevents hepatic steatosis by stabilizing phlpp2
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4557982e90754044bc5dda4f28d8a993
work_keys_str_mv	AT kyeongjinkim mtorc1independentraptorpreventshepaticsteatosisbystabilizingphlpp2 AT liqiang mtorc1independentraptorpreventshepaticsteatosisbystabilizingphlpp2 AT matthewshayden mtorc1independentraptorpreventshepaticsteatosisbystabilizingphlpp2 AT davidpsparling mtorc1independentraptorpreventshepaticsteatosisbystabilizingphlpp2 AT nicolehpurcell mtorc1independentraptorpreventshepaticsteatosisbystabilizingphlpp2 AT utpalbpajvani mtorc1independentraptorpreventshepaticsteatosisbystabilizingphlpp2
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mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2

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