RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break ends.
Resection of DNA double-strand break (DSB) ends is generally considered a critical determinant in pathways of DSB repair and genome stability. Unlike for enzymatically induced site-specific DSBs, little is known about processing of random "dirty-ended" DSBs created by DNA damaging agents s...
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| Auteurs principaux: | , , , , , |
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| Format: | article |
| Langue: | EN |
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Public Library of Science (PLoS)
2009
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| Accès en ligne: | https://doaj.org/article/456e7452b8874470b01a8e61f3d54a07 |
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