DEVELOPMENT AND CHARACTERIZATION OF FOLIC ACID MICROPARTICLES FORMED BY SPRAY-DRYING WITH GUM ARABIC AND MALTODEXTRIN

The folic acid is an essential vitamin, it is involved in the essential aminoacids biosynthesis and some process associated to DNA. Folic acid undergoes degradation reactions when is exposed to light, acid or alkaline medium and oxygen atmosphere. For this reason it is necessary to develop strategie...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Seneida M. LOPERA C., Cielo GUZMÁN O., Carlos CATAÑO R., Cecilia GALLARDO C.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	folic acid microparticles arabic gum maltodextrin Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/4588b67bd8b04f3f8e8c6a37c9a29a9a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4588b67bd8b04f3f8e8c6a37c9a29a9a
record_format	dspace
spelling	oai:doaj.org-article:4588b67bd8b04f3f8e8c6a37c9a29a9a2021-11-19T04:16:34ZDEVELOPMENT AND CHARACTERIZATION OF FOLIC ACID MICROPARTICLES FORMED BY SPRAY-DRYING WITH GUM ARABIC AND MALTODEXTRIN0121-40042145-2660https://doaj.org/article/4588b67bd8b04f3f8e8c6a37c9a29a9a2009-05-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/1426https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660The folic acid is an essential vitamin, it is involved in the essential aminoacids biosynthesis and some process associated to DNA. Folic acid undergoes degradation reactions when is exposed to light, acid or alkaline medium and oxygen atmosphere. For this reason it is necessary to develop strategies to improve its stability not affecting its biological activity. In this connection the obtaining of microparticles by spray drying, using arabic gum and maltodextrin blends is proposed. The microparticles could act as a carrier of folic acid providing it protection. In this study, microparticles of folic acid were obtained using four different blends of arabic gum and maltodextrin. The particles size distribution, morphology, encapsulation efficiency and dissolution profile were assessed for the different types of microparticles. The results showed different aspects: the microparticles morphology changed with the ratio arabic gum – maltodextrine, the encapsulation efficiency was high for four types of studied microparticles, the particles size distribution did not change with the wall materials ratio, the dissolution profiles showed a limited dissolution percentage, and microparticles of arabic gum-maltodextrin 70-30 showed the best profile. The arabic gum favored the encapsulation of folic acid and when it is mixed with maltodextrin the morphology, encapsulation efficiency and dissolution improved. Probably there is an optimum ratio of two wall materials providing optimum properties to microparticles. Seneida M. LOPERA C.Cielo GUZMÁN O.Carlos CATAÑO R.Cecilia GALLARDO C.Universidad de Antioquiaarticlefolic acidmicroparticlesarabic gummaltodextrinFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 16, Iss 1 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	folic acid microparticles arabic gum maltodextrin Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	folic acid microparticles arabic gum maltodextrin Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Seneida M. LOPERA C. Cielo GUZMÁN O. Carlos CATAÑO R. Cecilia GALLARDO C. DEVELOPMENT AND CHARACTERIZATION OF FOLIC ACID MICROPARTICLES FORMED BY SPRAY-DRYING WITH GUM ARABIC AND MALTODEXTRIN
description	The folic acid is an essential vitamin, it is involved in the essential aminoacids biosynthesis and some process associated to DNA. Folic acid undergoes degradation reactions when is exposed to light, acid or alkaline medium and oxygen atmosphere. For this reason it is necessary to develop strategies to improve its stability not affecting its biological activity. In this connection the obtaining of microparticles by spray drying, using arabic gum and maltodextrin blends is proposed. The microparticles could act as a carrier of folic acid providing it protection. In this study, microparticles of folic acid were obtained using four different blends of arabic gum and maltodextrin. The particles size distribution, morphology, encapsulation efficiency and dissolution profile were assessed for the different types of microparticles. The results showed different aspects: the microparticles morphology changed with the ratio arabic gum – maltodextrine, the encapsulation efficiency was high for four types of studied microparticles, the particles size distribution did not change with the wall materials ratio, the dissolution profiles showed a limited dissolution percentage, and microparticles of arabic gum-maltodextrin 70-30 showed the best profile. The arabic gum favored the encapsulation of folic acid and when it is mixed with maltodextrin the morphology, encapsulation efficiency and dissolution improved. Probably there is an optimum ratio of two wall materials providing optimum properties to microparticles.
format	article
author	Seneida M. LOPERA C. Cielo GUZMÁN O. Carlos CATAÑO R. Cecilia GALLARDO C.
author_facet	Seneida M. LOPERA C. Cielo GUZMÁN O. Carlos CATAÑO R. Cecilia GALLARDO C.
author_sort	Seneida M. LOPERA C.
title	DEVELOPMENT AND CHARACTERIZATION OF FOLIC ACID MICROPARTICLES FORMED BY SPRAY-DRYING WITH GUM ARABIC AND MALTODEXTRIN
title_short	DEVELOPMENT AND CHARACTERIZATION OF FOLIC ACID MICROPARTICLES FORMED BY SPRAY-DRYING WITH GUM ARABIC AND MALTODEXTRIN
title_full	DEVELOPMENT AND CHARACTERIZATION OF FOLIC ACID MICROPARTICLES FORMED BY SPRAY-DRYING WITH GUM ARABIC AND MALTODEXTRIN
title_fullStr	DEVELOPMENT AND CHARACTERIZATION OF FOLIC ACID MICROPARTICLES FORMED BY SPRAY-DRYING WITH GUM ARABIC AND MALTODEXTRIN
title_full_unstemmed	DEVELOPMENT AND CHARACTERIZATION OF FOLIC ACID MICROPARTICLES FORMED BY SPRAY-DRYING WITH GUM ARABIC AND MALTODEXTRIN
title_sort	development and characterization of folic acid microparticles formed by spray-drying with gum arabic and maltodextrin
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/4588b67bd8b04f3f8e8c6a37c9a29a9a
work_keys_str_mv	AT seneidamloperac developmentandcharacterizationoffolicacidmicroparticlesformedbyspraydryingwithgumarabicandmaltodextrin AT cieloguzmano developmentandcharacterizationoffolicacidmicroparticlesformedbyspraydryingwithgumarabicandmaltodextrin AT carloscatanor developmentandcharacterizationoffolicacidmicroparticlesformedbyspraydryingwithgumarabicandmaltodextrin AT ceciliagallardoc developmentandcharacterizationoffolicacidmicroparticlesformedbyspraydryingwithgumarabicandmaltodextrin
_version_	1718420455291879424

DEVELOPMENT AND CHARACTERIZATION OF FOLIC ACID MICROPARTICLES FORMED BY SPRAY-DRYING WITH GUM ARABIC AND MALTODEXTRIN

Ejemplares similares