A multi-parameter, high-content, high-throughput screening platform to identify natural compounds that modulate insulin and Pdx1 expression.

A multi-parameter, high-content, high-throughput screening platform to identify natural compounds that modulate insulin and Pdx1 expression.

Diabetes is a devastating disease that is ultimately caused by the malfunction or loss of insulin-producing pancreatic beta-cells. Drugs capable of inducing the development of new beta-cells or improving the function or survival of existing beta-cells could conceivably cure this disease. We report a...

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Main Authors: Jessica A Hill, Marta Szabat, Corinne A Hoesli, Blair K Gage, Yu Hsuan C Yang, David E Williams, Michael J Riedel, Dan S Luciani, Tatyana B Kalynyak, Kevin Tsai, Ziliang Ao, Raymond J Andersen, Garth L Warnock, James M Piret, Timothy J Kieffer, James D Johnson
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2010
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/4597d03eed1c4485a31e9ca5441e029a
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https://doaj.org/article/4597d03eed1c4485a31e9ca5441e029a

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