Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration.

Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration.

<h4>Background</h4>Parkinson's disease (PD) is an adult-onset movement disorder of largely unknown etiology. We have previously shown that loss-of-function mutations of the mitochondrial protein kinase PINK1 (PTEN induced putative kinase 1) cause the recessive PARK6 variant of PD.&l...

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Auteurs principaux: Suzana Gispert, Filomena Ricciardi, Alexander Kurz, Mekhman Azizov, Hans-Hermann Hoepken, Dorothea Becker, Wolfgang Voos, Kristina Leuner, Walter E Müller, Alexei P Kudin, Wolfram S Kunz, Annabelle Zimmermann, Jochen Roeper, Dirk Wenzel, Marina Jendrach, Moisés García-Arencíbia, Javier Fernández-Ruiz, Leslie Huber, Hermann Rohrer, Miguel Barrera, Andreas S Reichert, Udo Rüb, Amy Chen, Robert L Nussbaum, Georg Auburger
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2009
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/45f68ab49b2d403fa1646e411e62f433
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https://doaj.org/article/45f68ab49b2d403fa1646e411e62f433

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