Microglia contact induces synapse formation in developing somatosensory cortex

Microglia contribute to shaping neural circuits in the developing brain. Here, the authors show that microglial contact with pyramidal neuron dendrites induces synapse formation in the developing somatosensory cortex, and ablation of microglia reduces synaptic connections from L4 to L2/3 neurons.

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Autores principales:	Akiko Miyamoto, Hiroaki Wake, Ayako Wendy Ishikawa, Kei Eto, Keisuke Shibata, Hideji Murakoshi, Schuichi Koizumi, Andrew J. Moorhouse, Yumiko Yoshimura, Junichi Nabekura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/45fff4d674a54f38b5ae086508a1e2b5
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spelling	oai:doaj.org-article:45fff4d674a54f38b5ae086508a1e2b52021-12-02T16:58:23ZMicroglia contact induces synapse formation in developing somatosensory cortex10.1038/ncomms125402041-1723https://doaj.org/article/45fff4d674a54f38b5ae086508a1e2b52016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12540https://doaj.org/toc/2041-1723Microglia contribute to shaping neural circuits in the developing brain. Here, the authors show that microglial contact with pyramidal neuron dendrites induces synapse formation in the developing somatosensory cortex, and ablation of microglia reduces synaptic connections from L4 to L2/3 neurons.Akiko MiyamotoHiroaki WakeAyako Wendy IshikawaKei EtoKeisuke ShibataHideji MurakoshiSchuichi KoizumiAndrew J. MoorhouseYumiko YoshimuraJunichi NabekuraNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Akiko Miyamoto Hiroaki Wake Ayako Wendy Ishikawa Kei Eto Keisuke Shibata Hideji Murakoshi Schuichi Koizumi Andrew J. Moorhouse Yumiko Yoshimura Junichi Nabekura Microglia contact induces synapse formation in developing somatosensory cortex
description	Microglia contribute to shaping neural circuits in the developing brain. Here, the authors show that microglial contact with pyramidal neuron dendrites induces synapse formation in the developing somatosensory cortex, and ablation of microglia reduces synaptic connections from L4 to L2/3 neurons.
format	article
author	Akiko Miyamoto Hiroaki Wake Ayako Wendy Ishikawa Kei Eto Keisuke Shibata Hideji Murakoshi Schuichi Koizumi Andrew J. Moorhouse Yumiko Yoshimura Junichi Nabekura
author_facet	Akiko Miyamoto Hiroaki Wake Ayako Wendy Ishikawa Kei Eto Keisuke Shibata Hideji Murakoshi Schuichi Koizumi Andrew J. Moorhouse Yumiko Yoshimura Junichi Nabekura
author_sort	Akiko Miyamoto
title	Microglia contact induces synapse formation in developing somatosensory cortex
title_short	Microglia contact induces synapse formation in developing somatosensory cortex
title_full	Microglia contact induces synapse formation in developing somatosensory cortex
title_fullStr	Microglia contact induces synapse formation in developing somatosensory cortex
title_full_unstemmed	Microglia contact induces synapse formation in developing somatosensory cortex
title_sort	microglia contact induces synapse formation in developing somatosensory cortex
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/45fff4d674a54f38b5ae086508a1e2b5
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Microglia contact induces synapse formation in developing somatosensory cortex

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