A threonyl-tRNA synthetase-mediated translation initiation machinery

A threonyl-tRNA synthetase-mediated translation initiation machinery

The initiation of translation is a highly regulated process that contributes to specific gene expression programs. Here the authors find that, in vertebrate, threonyl-tRNA synthetase (TRS) can act as a scaffold for the initiation machinery to stimulate the translation of a specific set of mRNAs.

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Autores principales: Seung Jae Jeong, Shinhye Park, Loi T. Nguyen, Jungwon Hwang, Eun-Young Lee, Hoi-Khoanh Giong, Jeong-Soo Lee, Ina Yoon, Ji-Hyun Lee, Jong Hyun Kim, Hoi Kyoung Kim, Doyeun Kim, Won Suk Yang, Seon-Young Kim, Chan Yong Lee, Kweon Yu, Nahum Sonenberg, Myung Hee Kim, Sunghoon Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/4626adc229bd48dc902ff7c0880575dc
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spelling oai:doaj.org-article:4626adc229bd48dc902ff7c0880575dc2021-12-02T14:39:02ZA threonyl-tRNA synthetase-mediated translation initiation machinery10.1038/s41467-019-09086-02041-1723https://doaj.org/article/4626adc229bd48dc902ff7c0880575dc2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09086-0https://doaj.org/toc/2041-1723The initiation of translation is a highly regulated process that contributes to specific gene expression programs. Here the authors find that, in vertebrate, threonyl-tRNA synthetase (TRS) can act as a scaffold for the initiation machinery to stimulate the translation of a specific set of mRNAs.Seung Jae JeongShinhye ParkLoi T. NguyenJungwon HwangEun-Young LeeHoi-Khoanh GiongJeong-Soo LeeIna YoonJi-Hyun LeeJong Hyun KimHoi Kyoung KimDoyeun KimWon Suk YangSeon-Young KimChan Yong LeeKweon YuNahum SonenbergMyung Hee KimSunghoon KimNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Seung Jae Jeong
Shinhye Park
Loi T. Nguyen
Jungwon Hwang
Eun-Young Lee
Hoi-Khoanh Giong
Jeong-Soo Lee
Ina Yoon
Ji-Hyun Lee
Jong Hyun Kim
Hoi Kyoung Kim
Doyeun Kim
Won Suk Yang
Seon-Young Kim
Chan Yong Lee
Kweon Yu
Nahum Sonenberg
Myung Hee Kim
Sunghoon Kim
A threonyl-tRNA synthetase-mediated translation initiation machinery
description The initiation of translation is a highly regulated process that contributes to specific gene expression programs. Here the authors find that, in vertebrate, threonyl-tRNA synthetase (TRS) can act as a scaffold for the initiation machinery to stimulate the translation of a specific set of mRNAs.
format article
author Seung Jae Jeong
Shinhye Park
Loi T. Nguyen
Jungwon Hwang
Eun-Young Lee
Hoi-Khoanh Giong
Jeong-Soo Lee
Ina Yoon
Ji-Hyun Lee
Jong Hyun Kim
Hoi Kyoung Kim
Doyeun Kim
Won Suk Yang
Seon-Young Kim
Chan Yong Lee
Kweon Yu
Nahum Sonenberg
Myung Hee Kim
Sunghoon Kim
author_facet Seung Jae Jeong
Shinhye Park
Loi T. Nguyen
Jungwon Hwang
Eun-Young Lee
Hoi-Khoanh Giong
Jeong-Soo Lee
Ina Yoon
Ji-Hyun Lee
Jong Hyun Kim
Hoi Kyoung Kim
Doyeun Kim
Won Suk Yang
Seon-Young Kim
Chan Yong Lee
Kweon Yu
Nahum Sonenberg
Myung Hee Kim
Sunghoon Kim
author_sort Seung Jae Jeong
title A threonyl-tRNA synthetase-mediated translation initiation machinery
title_short A threonyl-tRNA synthetase-mediated translation initiation machinery
title_full A threonyl-tRNA synthetase-mediated translation initiation machinery
title_fullStr A threonyl-tRNA synthetase-mediated translation initiation machinery
title_full_unstemmed A threonyl-tRNA synthetase-mediated translation initiation machinery
title_sort threonyl-trna synthetase-mediated translation initiation machinery
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/4626adc229bd48dc902ff7c0880575dc
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