Methanol-essential growth of Escherichia coli

Engineering synthetic methylotrophy remains challenging. Here, the authors engineer a methanol-essential E. coli by an in silico-guided multiple knockout approach and show a laboratory evolved strain can incorporate up to 24% methanol into core metabolites during growth.

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Autores principales: Fabian Meyer, Philipp Keller, Johannes Hartl, Olivier G. Gröninger, Patrick Kiefer, Julia A. Vorholt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/4654240b271f4b1c99e0ce6a7b6e08fb
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