Alpha lipoic acid attenuates ER stress and improves glucose uptake through DNAJB3 cochaperone

Abstract Persistent ER stress, mitochondrial dysfunction and failure of the heat shock response (HSR) are fundamental hallmarks of insulin resistance (IR); one of the early core metabolic aberrations that leads to type 2 diabetes (T2D). The antioxidant α-lipoic acid (ALA) has been shown to attenuate...

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Autores principales: Abdoulaye Diane, Naela Mahmoud, Ilham Bensmail, Namat Khattab, Hanan A. Abunada, Mohammed Dehbi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/465554f1f2074a2bbf23553f639d9bf4
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