Alpha lipoic acid attenuates ER stress and improves glucose uptake through DNAJB3 cochaperone

Abstract Persistent ER stress, mitochondrial dysfunction and failure of the heat shock response (HSR) are fundamental hallmarks of insulin resistance (IR); one of the early core metabolic aberrations that leads to type 2 diabetes (T2D). The antioxidant α-lipoic acid (ALA) has been shown to attenuate...

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Auteurs principaux: Abdoulaye Diane, Naela Mahmoud, Ilham Bensmail, Namat Khattab, Hanan A. Abunada, Mohammed Dehbi
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/465554f1f2074a2bbf23553f639d9bf4
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