SspABCD-SspFGH Constitutes a New Type of DNA Phosphorothioate-Based Bacterial Defense System

SspABCD-SspFGH Constitutes a New Type of DNA Phosphorothioate-Based Bacterial Defense System

We recently found that SspABCD, catalyzing single-stranded (ss) DNA phosphorothioate (PT) modification, coupled with SspE provides protection against phage infection. SspE performs both PT-simulated NTPase and DNA-nicking nuclease activities to damage phage DNA, rendering SspA-E a PT-sensing defens...

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Autores principales: Shiwei Wang, Mengping Wan, Ruolin Huang, Yujing Zhang, Yuqing Xie, Yue Wei, Mustafa Ahmad, Dan Wu, Yue Hong, Zixin Deng, Shi Chen, Zhiqiang Li, Lianrong Wang
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
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Microbiology
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Acceso en línea:https://doaj.org/article/46623d11ccdd4f248725aab1fe2fab08
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spelling oai:doaj.org-article:46623d11ccdd4f248725aab1fe2fab082021-11-03T18:56:09ZSspABCD-SspFGH Constitutes a New Type of DNA Phosphorothioate-Based Bacterial Defense System2150-751110.1128/mBio.00613-21https://doaj.org/article/46623d11ccdd4f248725aab1fe2fab082021-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00613-21https://doaj.org/toc/2150-7511 We recently found that SspABCD, catalyzing single-stranded (ss) DNA phosphorothioate (PT) modification, coupled with SspE provides protection against phage infection. SspE performs both PT-simulated NTPase and DNA-nicking nuclease activities to damage phage DNA, rendering SspA-E a PT-sensing defense system.Shiwei WangMengping WanRuolin HuangYujing ZhangYuqing XieYue WeiMustafa AhmadDan WuYue HongZixin DengShi ChenZhiqiang LiLianrong WangAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 2 (2021)
institution DOAJ
collection DOAJ
language EN
topic Microbiology
QR1-502
spellingShingle Microbiology
QR1-502
Shiwei Wang
Mengping Wan
Ruolin Huang
Yujing Zhang
Yuqing Xie
Yue Wei
Mustafa Ahmad
Dan Wu
Yue Hong
Zixin Deng
Shi Chen
Zhiqiang Li
Lianrong Wang
SspABCD-SspFGH Constitutes a New Type of DNA Phosphorothioate-Based Bacterial Defense System
description We recently found that SspABCD, catalyzing single-stranded (ss) DNA phosphorothioate (PT) modification, coupled with SspE provides protection against phage infection. SspE performs both PT-simulated NTPase and DNA-nicking nuclease activities to damage phage DNA, rendering SspA-E a PT-sensing defense system.
format article
author Shiwei Wang
Mengping Wan
Ruolin Huang
Yujing Zhang
Yuqing Xie
Yue Wei
Mustafa Ahmad
Dan Wu
Yue Hong
Zixin Deng
Shi Chen
Zhiqiang Li
Lianrong Wang
author_facet Shiwei Wang
Mengping Wan
Ruolin Huang
Yujing Zhang
Yuqing Xie
Yue Wei
Mustafa Ahmad
Dan Wu
Yue Hong
Zixin Deng
Shi Chen
Zhiqiang Li
Lianrong Wang
author_sort Shiwei Wang
title SspABCD-SspFGH Constitutes a New Type of DNA Phosphorothioate-Based Bacterial Defense System
title_short SspABCD-SspFGH Constitutes a New Type of DNA Phosphorothioate-Based Bacterial Defense System
title_full SspABCD-SspFGH Constitutes a New Type of DNA Phosphorothioate-Based Bacterial Defense System
title_fullStr SspABCD-SspFGH Constitutes a New Type of DNA Phosphorothioate-Based Bacterial Defense System
title_full_unstemmed SspABCD-SspFGH Constitutes a New Type of DNA Phosphorothioate-Based Bacterial Defense System
title_sort sspabcd-sspfgh constitutes a new type of dna phosphorothioate-based bacterial defense system
publisher American Society for Microbiology
publishDate 2021
url https://doaj.org/article/46623d11ccdd4f248725aab1fe2fab08
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