ChAdOx1-vectored Lassa fever vaccine elicits a robust cellular and humoral immune response and protects guinea pigs against lethal Lassa virus challenge

ChAdOx1-vectored Lassa fever vaccine elicits a robust cellular and humoral immune response and protects guinea pigs against lethal Lassa virus challenge

Abstract Lassa virus (LASV) infects hundreds of thousands of individuals each year, highlighting the need for the accelerated development of preventive, diagnostic, and therapeutic interventions. To date, no vaccine has been licensed for LASV. ChAdOx1-Lassa-GPC is a chimpanzee adenovirus-vectored va...

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Détails bibliographiques
Auteurs principaux: Robert J. Fischer, Jyothi N. Purushotham, Neeltje van Doremalen, Sarah Sebastian, Kimberly Meade-White, Kathleen Cordova, Michael Letko, M. Jeremiah Matson, Friederike Feldmann, Elaine Haddock, Rachel LaCasse, Greg Saturday, Teresa Lambe, Sarah C. Gilbert, Vincent J. Munster
Format: article
Langue:EN
Publié: Nature Portfolio 2021
Sujets:
Immunologic diseases. Allergy
RC581-607
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Accès en ligne:https://doaj.org/article/4667aaafa6c240a492ef4c7b8f637c7b
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https://doaj.org/article/4667aaafa6c240a492ef4c7b8f637c7b

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