The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity

Transcription factors MarR and MarA confer multidrug resistance in enteric bacteria by modulating efflux pump and porin expression. Here, Sharma et al. show that MarA also upregulates genes required for lipid trafficking and DNA repair, thus reducing antibiotic entry and quinolone-induced DNA damage...

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Autores principales: Prateek Sharma, James R. J. Haycocks, Alistair D. Middlemiss, Rachel A. Kettles, Laura E. Sellars, Vito Ricci, Laura J. V. Piddock, David C. Grainger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/4669c1bf8a8f4a01bd835687185dcfd1
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