The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity

Transcription factors MarR and MarA confer multidrug resistance in enteric bacteria by modulating efflux pump and porin expression. Here, Sharma et al. show that MarA also upregulates genes required for lipid trafficking and DNA repair, thus reducing antibiotic entry and quinolone-induced DNA damage...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Prateek Sharma, James R. J. Haycocks, Alistair D. Middlemiss, Rachel A. Kettles, Laura E. Sellars, Vito Ricci, Laura J. V. Piddock, David C. Grainger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4669c1bf8a8f4a01bd835687185dcfd1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4669c1bf8a8f4a01bd835687185dcfd1
record_format	dspace
spelling	oai:doaj.org-article:4669c1bf8a8f4a01bd835687185dcfd12021-12-02T14:40:32ZThe multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity10.1038/s41467-017-01405-72041-1723https://doaj.org/article/4669c1bf8a8f4a01bd835687185dcfd12017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01405-7https://doaj.org/toc/2041-1723Transcription factors MarR and MarA confer multidrug resistance in enteric bacteria by modulating efflux pump and porin expression. Here, Sharma et al. show that MarA also upregulates genes required for lipid trafficking and DNA repair, thus reducing antibiotic entry and quinolone-induced DNA damage.Prateek SharmaJames R. J. HaycocksAlistair D. MiddlemissRachel A. KettlesLaura E. SellarsVito RicciLaura J. V. PiddockDavid C. GraingerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Prateek Sharma James R. J. Haycocks Alistair D. Middlemiss Rachel A. Kettles Laura E. Sellars Vito Ricci Laura J. V. Piddock David C. Grainger The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity
description	Transcription factors MarR and MarA confer multidrug resistance in enteric bacteria by modulating efflux pump and porin expression. Here, Sharma et al. show that MarA also upregulates genes required for lipid trafficking and DNA repair, thus reducing antibiotic entry and quinolone-induced DNA damage.
format	article
author	Prateek Sharma James R. J. Haycocks Alistair D. Middlemiss Rachel A. Kettles Laura E. Sellars Vito Ricci Laura J. V. Piddock David C. Grainger
author_facet	Prateek Sharma James R. J. Haycocks Alistair D. Middlemiss Rachel A. Kettles Laura E. Sellars Vito Ricci Laura J. V. Piddock David C. Grainger
author_sort	Prateek Sharma
title	The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity
title_short	The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity
title_full	The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity
title_fullStr	The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity
title_full_unstemmed	The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity
title_sort	multiple antibiotic resistance operon of enteric bacteria controls dna repair and outer membrane integrity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4669c1bf8a8f4a01bd835687185dcfd1
work_keys_str_mv	AT prateeksharma themultipleantibioticresistanceoperonofentericbacteriacontrolsdnarepairandoutermembraneintegrity AT jamesrjhaycocks themultipleantibioticresistanceoperonofentericbacteriacontrolsdnarepairandoutermembraneintegrity AT alistairdmiddlemiss themultipleantibioticresistanceoperonofentericbacteriacontrolsdnarepairandoutermembraneintegrity AT rachelakettles themultipleantibioticresistanceoperonofentericbacteriacontrolsdnarepairandoutermembraneintegrity AT lauraesellars themultipleantibioticresistanceoperonofentericbacteriacontrolsdnarepairandoutermembraneintegrity AT vitoricci themultipleantibioticresistanceoperonofentericbacteriacontrolsdnarepairandoutermembraneintegrity AT laurajvpiddock themultipleantibioticresistanceoperonofentericbacteriacontrolsdnarepairandoutermembraneintegrity AT davidcgrainger themultipleantibioticresistanceoperonofentericbacteriacontrolsdnarepairandoutermembraneintegrity AT prateeksharma multipleantibioticresistanceoperonofentericbacteriacontrolsdnarepairandoutermembraneintegrity AT jamesrjhaycocks multipleantibioticresistanceoperonofentericbacteriacontrolsdnarepairandoutermembraneintegrity AT alistairdmiddlemiss multipleantibioticresistanceoperonofentericbacteriacontrolsdnarepairandoutermembraneintegrity AT rachelakettles multipleantibioticresistanceoperonofentericbacteriacontrolsdnarepairandoutermembraneintegrity AT lauraesellars multipleantibioticresistanceoperonofentericbacteriacontrolsdnarepairandoutermembraneintegrity AT vitoricci multipleantibioticresistanceoperonofentericbacteriacontrolsdnarepairandoutermembraneintegrity AT laurajvpiddock multipleantibioticresistanceoperonofentericbacteriacontrolsdnarepairandoutermembraneintegrity AT davidcgrainger multipleantibioticresistanceoperonofentericbacteriacontrolsdnarepairandoutermembraneintegrity
_version_	1718390234262011904

The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity

Ejemplares similares