Exercise-induced changes in climbing performance

Exercise is recommended to promote health and prevent a range of diseases. However, how exercise precipitates these benefits is unclear, nor do we understand why exercise responses differ so widely between individuals. We investigate how climbing ability in Drosophila melanogaster changes in respons...

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Autores principales:	Louis P. Watanabe, Nicole C. Riddle
Formato:	article
Lenguaje:	EN
Publicado:	The Royal Society 2021
Materias:	Drosophila physical fitness climbing exercise DGRP GWAS Science Q
Acceso en línea:	https://doaj.org/article/46884ed9026f44abb57dc7d7daefb154
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spelling	oai:doaj.org-article:46884ed9026f44abb57dc7d7daefb1542021-11-10T08:06:33ZExercise-induced changes in climbing performance10.1098/rsos.2112752054-5703https://doaj.org/article/46884ed9026f44abb57dc7d7daefb1542021-11-01T00:00:00Zhttps://royalsocietypublishing.org/doi/10.1098/rsos.211275https://doaj.org/toc/2054-5703Exercise is recommended to promote health and prevent a range of diseases. However, how exercise precipitates these benefits is unclear, nor do we understand why exercise responses differ so widely between individuals. We investigate how climbing ability in Drosophila melanogaster changes in response to an exercise treatment. We find extensive variation in baseline climbing ability and exercise-induced changes ranging from −13% to +20% in climbing ability. Climbing ability, and its exercise-induced change, is sex- and genotype-dependent. GWASs implicate ‘cell–cell signalling’ genes in the control of climbing ability. We also find that animal activity does not predict climbing ability and that the exercise-induced climbing ability change cannot be predicted from the activity level induced by the exercise treatment. These results provide promising new avenues for further research into the molecular pathways controlling climbing activity and illustrate the complexities involved in trying to predict individual responses to exercise.Louis P. WatanabeNicole C. RiddleThe Royal SocietyarticleDrosophilaphysical fitnessclimbingexerciseDGRPGWASScienceQENRoyal Society Open Science, Vol 8, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Drosophila physical fitness climbing exercise DGRP GWAS Science Q
spellingShingle	Drosophila physical fitness climbing exercise DGRP GWAS Science Q Louis P. Watanabe Nicole C. Riddle Exercise-induced changes in climbing performance
description	Exercise is recommended to promote health and prevent a range of diseases. However, how exercise precipitates these benefits is unclear, nor do we understand why exercise responses differ so widely between individuals. We investigate how climbing ability in Drosophila melanogaster changes in response to an exercise treatment. We find extensive variation in baseline climbing ability and exercise-induced changes ranging from −13% to +20% in climbing ability. Climbing ability, and its exercise-induced change, is sex- and genotype-dependent. GWASs implicate ‘cell–cell signalling’ genes in the control of climbing ability. We also find that animal activity does not predict climbing ability and that the exercise-induced climbing ability change cannot be predicted from the activity level induced by the exercise treatment. These results provide promising new avenues for further research into the molecular pathways controlling climbing activity and illustrate the complexities involved in trying to predict individual responses to exercise.
format	article
author	Louis P. Watanabe Nicole C. Riddle
author_facet	Louis P. Watanabe Nicole C. Riddle
author_sort	Louis P. Watanabe
title	Exercise-induced changes in climbing performance
title_short	Exercise-induced changes in climbing performance
title_full	Exercise-induced changes in climbing performance
title_fullStr	Exercise-induced changes in climbing performance
title_full_unstemmed	Exercise-induced changes in climbing performance
title_sort	exercise-induced changes in climbing performance
publisher	The Royal Society
publishDate	2021
url	https://doaj.org/article/46884ed9026f44abb57dc7d7daefb154
work_keys_str_mv	AT louispwatanabe exerciseinducedchangesinclimbingperformance AT nicolecriddle exerciseinducedchangesinclimbingperformance
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Exercise-induced changes in climbing performance

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