Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion

Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion

Retinal vein occlusion can cause blindness, and features neuronal dysfunction, inflammation and breakdown of vascular integrity. Here the authors report a non-apoptotic role of endothelial caspase-9 in regulating blood-retina barrier integrity and neuronal survival, which can be therapeutically targ...

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Autores principales: Maria I. Avrutsky, Crystal Colón Ortiz, Kendra V. Johnson, Anna M. Potenski, Claire W. Chen, Jacqueline M. Lawson, Alexandra J. White, Stephanie K. Yuen, Fatima N. Morales, Elisa Canepa, Scott Snipas, Guy S. Salvesen, Ying Y. Jean, Carol M. Troy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/4688da8d4e524bccb33f889dc5ad0823
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https://doaj.org/article/4688da8d4e524bccb33f889dc5ad0823

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