Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion

Retinal vein occlusion can cause blindness, and features neuronal dysfunction, inflammation and breakdown of vascular integrity. Here the authors report a non-apoptotic role of endothelial caspase-9 in regulating blood-retina barrier integrity and neuronal survival, which can be therapeutically targ...

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Autores principales:	Maria I. Avrutsky, Crystal Colón Ortiz, Kendra V. Johnson, Anna M. Potenski, Claire W. Chen, Jacqueline M. Lawson, Alexandra J. White, Stephanie K. Yuen, Fatima N. Morales, Elisa Canepa, Scott Snipas, Guy S. Salvesen, Ying Y. Jean, Carol M. Troy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4688da8d4e524bccb33f889dc5ad0823
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spelling	oai:doaj.org-article:4688da8d4e524bccb33f889dc5ad08232021-12-02T17:12:20ZEndothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion10.1038/s41467-020-16902-52041-1723https://doaj.org/article/4688da8d4e524bccb33f889dc5ad08232020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16902-5https://doaj.org/toc/2041-1723Retinal vein occlusion can cause blindness, and features neuronal dysfunction, inflammation and breakdown of vascular integrity. Here the authors report a non-apoptotic role of endothelial caspase-9 in regulating blood-retina barrier integrity and neuronal survival, which can be therapeutically targeted in a mouse model of retinal vein occlusion.Maria I. AvrutskyCrystal Colón OrtizKendra V. JohnsonAnna M. PotenskiClaire W. ChenJacqueline M. LawsonAlexandra J. WhiteStephanie K. YuenFatima N. MoralesElisa CanepaScott SnipasGuy S. SalvesenYing Y. JeanCarol M. TroyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria I. Avrutsky Crystal Colón Ortiz Kendra V. Johnson Anna M. Potenski Claire W. Chen Jacqueline M. Lawson Alexandra J. White Stephanie K. Yuen Fatima N. Morales Elisa Canepa Scott Snipas Guy S. Salvesen Ying Y. Jean Carol M. Troy Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion
description	Retinal vein occlusion can cause blindness, and features neuronal dysfunction, inflammation and breakdown of vascular integrity. Here the authors report a non-apoptotic role of endothelial caspase-9 in regulating blood-retina barrier integrity and neuronal survival, which can be therapeutically targeted in a mouse model of retinal vein occlusion.
format	article
author	Maria I. Avrutsky Crystal Colón Ortiz Kendra V. Johnson Anna M. Potenski Claire W. Chen Jacqueline M. Lawson Alexandra J. White Stephanie K. Yuen Fatima N. Morales Elisa Canepa Scott Snipas Guy S. Salvesen Ying Y. Jean Carol M. Troy
author_facet	Maria I. Avrutsky Crystal Colón Ortiz Kendra V. Johnson Anna M. Potenski Claire W. Chen Jacqueline M. Lawson Alexandra J. White Stephanie K. Yuen Fatima N. Morales Elisa Canepa Scott Snipas Guy S. Salvesen Ying Y. Jean Carol M. Troy
author_sort	Maria I. Avrutsky
title	Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion
title_short	Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion
title_full	Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion
title_fullStr	Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion
title_full_unstemmed	Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion
title_sort	endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4688da8d4e524bccb33f889dc5ad0823
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Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion

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