Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21.

Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21.

In pathogenic HIV and SIV infections of humans and rhesus macaques (RMs), preferential depletion of CD4⁺ Th17 cells correlates with mucosal immune dysfunction and disease progression. Interleukin (IL)-21 promotes differentiation of Th17 cells, long-term maintenance of functional CD8⁺ T cells, and di...

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Detalles Bibliográficos
Autores principales: Suresh Pallikkuth, Luca Micci, Zachary S Ende, Robin I Iriele, Barbara Cervasi, Benton Lawson, Colleen S McGary, Kenneth A Rogers, James G Else, Guido Silvestri, Kirk Easley, Jacob D Estes, Francois Villinger, Savita Pahwa, Mirko Paiardini
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/469083600eb542f78336284afc46cd6b
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https://doaj.org/article/469083600eb542f78336284afc46cd6b

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