Synthetic CRISPR-Cas gene activators for transcriptional reprogramming in bacteria

The absence of effective gene activators in bacteria limits regulated expression programs. Here the authors design synthetic bacterial CRISPR-Cas transcriptional activators that can be used to construct multi-gene programs of activation and repression.

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Autores principales: Chen Dong, Jason Fontana, Anika Patel, James M. Carothers, Jesse G. Zalatan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/4698bcb289ae4ad39b0b62c50044470c
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