Synthetic CRISPR-Cas gene activators for transcriptional reprogramming in bacteria

The absence of effective gene activators in bacteria limits regulated expression programs. Here the authors design synthetic bacterial CRISPR-Cas transcriptional activators that can be used to construct multi-gene programs of activation and repression.

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Autores principales:	Chen Dong, Jason Fontana, Anika Patel, James M. Carothers, Jesse G. Zalatan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4698bcb289ae4ad39b0b62c50044470c
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spelling	oai:doaj.org-article:4698bcb289ae4ad39b0b62c50044470c2021-12-02T15:34:37ZSynthetic CRISPR-Cas gene activators for transcriptional reprogramming in bacteria10.1038/s41467-018-04901-62041-1723https://doaj.org/article/4698bcb289ae4ad39b0b62c50044470c2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04901-6https://doaj.org/toc/2041-1723The absence of effective gene activators in bacteria limits regulated expression programs. Here the authors design synthetic bacterial CRISPR-Cas transcriptional activators that can be used to construct multi-gene programs of activation and repression.Chen DongJason FontanaAnika PatelJames M. CarothersJesse G. ZalatanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chen Dong Jason Fontana Anika Patel James M. Carothers Jesse G. Zalatan Synthetic CRISPR-Cas gene activators for transcriptional reprogramming in bacteria
description	The absence of effective gene activators in bacteria limits regulated expression programs. Here the authors design synthetic bacterial CRISPR-Cas transcriptional activators that can be used to construct multi-gene programs of activation and repression.
format	article
author	Chen Dong Jason Fontana Anika Patel James M. Carothers Jesse G. Zalatan
author_facet	Chen Dong Jason Fontana Anika Patel James M. Carothers Jesse G. Zalatan
author_sort	Chen Dong
title	Synthetic CRISPR-Cas gene activators for transcriptional reprogramming in bacteria
title_short	Synthetic CRISPR-Cas gene activators for transcriptional reprogramming in bacteria
title_full	Synthetic CRISPR-Cas gene activators for transcriptional reprogramming in bacteria
title_fullStr	Synthetic CRISPR-Cas gene activators for transcriptional reprogramming in bacteria
title_full_unstemmed	Synthetic CRISPR-Cas gene activators for transcriptional reprogramming in bacteria
title_sort	synthetic crispr-cas gene activators for transcriptional reprogramming in bacteria
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4698bcb289ae4ad39b0b62c50044470c
work_keys_str_mv	AT chendong syntheticcrisprcasgeneactivatorsfortranscriptionalreprogramminginbacteria AT jasonfontana syntheticcrisprcasgeneactivatorsfortranscriptionalreprogramminginbacteria AT anikapatel syntheticcrisprcasgeneactivatorsfortranscriptionalreprogramminginbacteria AT jamesmcarothers syntheticcrisprcasgeneactivatorsfortranscriptionalreprogramminginbacteria AT jessegzalatan syntheticcrisprcasgeneactivatorsfortranscriptionalreprogramminginbacteria
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Synthetic CRISPR-Cas gene activators for transcriptional reprogramming in bacteria

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