HOXA13 in etiology and oncogenic potential of Barrett’s esophagus

Barrett’s esophagus is a pro-oncogenic lesion in the proximal gastrointestinal tract, but with a distal colon-like morphology. Here the authors report that the distal HOX gene HOXA13 is expressed in Barrett’s esophagus and in single cells of the physiological esophagus, and may underlie the phenotyp...

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Autores principales:	Vincent T. Janmaat, Kateryna Nesteruk, Manon C. W. Spaander, Auke P. Verhaar, Bingting Yu, Rodrigo A. Silva, Wayne A. Phillips, Marcin Magierowski, Anouk van de Winkel, H. Scott Stadler, Tatiana Sandoval-Guzmán, Luc J. W. van der Laan, Ernst J. Kuipers, Ron Smits, Marco J. Bruno, Gwenny M. Fuhler, Nicholas J. Clemons, Maikel P. Peppelenbosch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/469f4cbf24264d01b938927512f6b9a2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:469f4cbf24264d01b938927512f6b9a22021-12-02T17:47:14ZHOXA13 in etiology and oncogenic potential of Barrett’s esophagus10.1038/s41467-021-23641-82041-1723https://doaj.org/article/469f4cbf24264d01b938927512f6b9a22021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23641-8https://doaj.org/toc/2041-1723Barrett’s esophagus is a pro-oncogenic lesion in the proximal gastrointestinal tract, but with a distal colon-like morphology. Here the authors report that the distal HOX gene HOXA13 is expressed in Barrett’s esophagus and in single cells of the physiological esophagus, and may underlie the phenotypic aspects of metaplasia and increase proliferation.Vincent T. JanmaatKateryna NesterukManon C. W. SpaanderAuke P. VerhaarBingting YuRodrigo A. SilvaWayne A. PhillipsMarcin MagierowskiAnouk van de WinkelH. Scott StadlerTatiana Sandoval-GuzmánLuc J. W. van der LaanErnst J. KuipersRon SmitsMarco J. BrunoGwenny M. FuhlerNicholas J. ClemonsMaikel P. PeppelenboschNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vincent T. Janmaat Kateryna Nesteruk Manon C. W. Spaander Auke P. Verhaar Bingting Yu Rodrigo A. Silva Wayne A. Phillips Marcin Magierowski Anouk van de Winkel H. Scott Stadler Tatiana Sandoval-Guzmán Luc J. W. van der Laan Ernst J. Kuipers Ron Smits Marco J. Bruno Gwenny M. Fuhler Nicholas J. Clemons Maikel P. Peppelenbosch HOXA13 in etiology and oncogenic potential of Barrett’s esophagus
description	Barrett’s esophagus is a pro-oncogenic lesion in the proximal gastrointestinal tract, but with a distal colon-like morphology. Here the authors report that the distal HOX gene HOXA13 is expressed in Barrett’s esophagus and in single cells of the physiological esophagus, and may underlie the phenotypic aspects of metaplasia and increase proliferation.
format	article
author	Vincent T. Janmaat Kateryna Nesteruk Manon C. W. Spaander Auke P. Verhaar Bingting Yu Rodrigo A. Silva Wayne A. Phillips Marcin Magierowski Anouk van de Winkel H. Scott Stadler Tatiana Sandoval-Guzmán Luc J. W. van der Laan Ernst J. Kuipers Ron Smits Marco J. Bruno Gwenny M. Fuhler Nicholas J. Clemons Maikel P. Peppelenbosch
author_facet	Vincent T. Janmaat Kateryna Nesteruk Manon C. W. Spaander Auke P. Verhaar Bingting Yu Rodrigo A. Silva Wayne A. Phillips Marcin Magierowski Anouk van de Winkel H. Scott Stadler Tatiana Sandoval-Guzmán Luc J. W. van der Laan Ernst J. Kuipers Ron Smits Marco J. Bruno Gwenny M. Fuhler Nicholas J. Clemons Maikel P. Peppelenbosch
author_sort	Vincent T. Janmaat
title	HOXA13 in etiology and oncogenic potential of Barrett’s esophagus
title_short	HOXA13 in etiology and oncogenic potential of Barrett’s esophagus
title_full	HOXA13 in etiology and oncogenic potential of Barrett’s esophagus
title_fullStr	HOXA13 in etiology and oncogenic potential of Barrett’s esophagus
title_full_unstemmed	HOXA13 in etiology and oncogenic potential of Barrett’s esophagus
title_sort	hoxa13 in etiology and oncogenic potential of barrett’s esophagus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/469f4cbf24264d01b938927512f6b9a2
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HOXA13 in etiology and oncogenic potential of Barrett’s esophagus

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