Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis

In breast cancer, the loss of expression of WW domain-containing oxireductase (Wwox) has been observed. Here, the authors illustrate that in triple negative breast cancer models Wwox suppresses metastasis and proliferation via the JAK2/STAT3 pathway.

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Autores principales:	Renxu Chang, Lele Song, Yi Xu, Yanjun Wu, Cheng Dai, Xinyu Wang, Xia Sun, Yingyong Hou, Wei Li, Xianbao Zhan, Lixing Zhan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/46a1268fb89a419cb3100d7ee1428ee9
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spelling	oai:doaj.org-article:46a1268fb89a419cb3100d7ee1428ee92021-12-02T17:33:16ZLoss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis10.1038/s41467-018-05852-82041-1723https://doaj.org/article/46a1268fb89a419cb3100d7ee1428ee92018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05852-8https://doaj.org/toc/2041-1723In breast cancer, the loss of expression of WW domain-containing oxireductase (Wwox) has been observed. Here, the authors illustrate that in triple negative breast cancer models Wwox suppresses metastasis and proliferation via the JAK2/STAT3 pathway.Renxu ChangLele SongYi XuYanjun WuCheng DaiXinyu WangXia SunYingyong HouWei LiXianbao ZhanLixing ZhanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Renxu Chang Lele Song Yi Xu Yanjun Wu Cheng Dai Xinyu Wang Xia Sun Yingyong Hou Wei Li Xianbao Zhan Lixing Zhan Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis
description	In breast cancer, the loss of expression of WW domain-containing oxireductase (Wwox) has been observed. Here, the authors illustrate that in triple negative breast cancer models Wwox suppresses metastasis and proliferation via the JAK2/STAT3 pathway.
format	article
author	Renxu Chang Lele Song Yi Xu Yanjun Wu Cheng Dai Xinyu Wang Xia Sun Yingyong Hou Wei Li Xianbao Zhan Lixing Zhan
author_facet	Renxu Chang Lele Song Yi Xu Yanjun Wu Cheng Dai Xinyu Wang Xia Sun Yingyong Hou Wei Li Xianbao Zhan Lixing Zhan
author_sort	Renxu Chang
title	Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis
title_short	Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis
title_full	Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis
title_fullStr	Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis
title_full_unstemmed	Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis
title_sort	loss of wwox drives metastasis in triple-negative breast cancer by jak2/stat3 axis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/46a1268fb89a419cb3100d7ee1428ee9
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Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis

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