Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis

Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis

In breast cancer, the loss of expression of WW domain-containing oxireductase (Wwox) has been observed. Here, the authors illustrate that in triple negative breast cancer models Wwox suppresses metastasis and proliferation via the JAK2/STAT3 pathway.

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Detalles Bibliográficos
Autores principales: Renxu Chang, Lele Song, Yi Xu, Yanjun Wu, Cheng Dai, Xinyu Wang, Xia Sun, Yingyong Hou, Wei Li, Xianbao Zhan, Lixing Zhan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/46a1268fb89a419cb3100d7ee1428ee9
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